{"id":318,"title":"Glucocorticoid Receptor activation leading to hepatic steatosis","short_name":"GR activation leading to hepatic steatosis","created_at":"2020-02-22T08:39:30.000-05:00","updated_at":"2023-09-25T16:27:01.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":122,"event":"Activation, Glucocorticoid Receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1834,"event":"Decrease, Acyl-CoA dehydrogenases","event_type":"KeyEvent"},{"event_id":860,"event":"Decreased, Mitochondrial Fatty Acid Beta Oxidation","event_type":"KeyEvent"},{"event_id":291,"event":"Accumulation, Triglyceride","event_type":"KeyEvent"}],"aop_aos":[{"event_id":459,"event":"Increased, Liver Steatosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":2488,"upstream_event_id":122,"upstream_event":"Activation, Glucocorticoid Receptor","downstream_event_id":1834,"downstream_event":"Decrease, Acyl-CoA dehydrogenases"},{"relation":2486,"upstream_event_id":1834,"upstream_event":"Decrease, Acyl-CoA dehydrogenases","downstream_event_id":860,"downstream_event":"Decreased, Mitochondrial Fatty Acid Beta Oxidation"},{"relation":2483,"upstream_event_id":860,"upstream_event":"Decreased, Mitochondrial Fatty Acid Beta Oxidation","downstream_event_id":291,"downstream_event":"Accumulation, Triglyceride"},{"relation":2487,"upstream_event_id":291,"upstream_event":"Accumulation, Triglyceride","downstream_event_id":459,"downstream_event":"Increased, Liver Steatosis"}]}