{"id":316,"title":"Trypsin inhibition leading to pancreatic acinar cell tumors","short_name":"TI-induced AC tumors","created_at":"2020-01-08T00:45:04.000-05:00","updated_at":"2023-09-25T16:27:01.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1720,"event":"Trypsin inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1721,"event":"Increased intestinal monitor peptide level","event_type":"KeyEvent"},{"event_id":1722,"event":"Increased blood CCK level","event_type":"KeyEvent"},{"event_id":1723,"event":"Increased exocrine secretion from pancreatic acinar cells","event_type":"KeyEvent"},{"event_id":1724,"event":"Acinar cell proliferation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1725,"event":"Pancreatic acinar cell tumors","event_type":"AdverseOutcome"}],"relationships":[{"relation":2055,"upstream_event_id":1720,"upstream_event":"Trypsin inhibition","downstream_event_id":1721,"downstream_event":"Increased intestinal monitor peptide level"},{"relation":2056,"upstream_event_id":1721,"upstream_event":"Increased intestinal monitor peptide level","downstream_event_id":1722,"downstream_event":"Increased blood CCK level"},{"relation":2057,"upstream_event_id":1722,"upstream_event":"Increased blood CCK level","downstream_event_id":1723,"downstream_event":"Increased exocrine secretion from pancreatic acinar cells"},{"relation":2058,"upstream_event_id":1723,"upstream_event":"Increased exocrine secretion from pancreatic acinar cells","downstream_event_id":1724,"downstream_event":"Acinar cell proliferation"},{"relation":2059,"upstream_event_id":1724,"upstream_event":"Acinar cell proliferation","downstream_event_id":1725,"downstream_event":"Pancreatic acinar cell tumors"}]}