{"id":313,"title":"Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease","short_name":"Skin disease by stimulation of TLR7/8","created_at":"2019-12-27T04:09:57.000-05:00","updated_at":"2023-09-25T16:27:01.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":519,"stressor_name":"Imiquimod"},{"stressor_id":520,"stressor_name":"Resiquimod"}],"aop_mies":[{"event_id":1706,"event":"Stimulation, TLR7/8","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1822,"event":"Maturation of TNF/iNOS-Producing Dendritic Cells","event_type":"KeyEvent"},{"event_id":1707,"event":"Increase, IL-23 from matured dendritic cells","event_type":"KeyEvent"},{"event_id":1708,"event":"Th17 cell migration and inflammation induction","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1709,"event":"Psoriatic skin disease","event_type":"AdverseOutcome"}],"relationships":[{"relation":2044,"upstream_event_id":1706,"upstream_event":"Stimulation, TLR7/8","downstream_event_id":1707,"downstream_event":"Increase, IL-23 from matured dendritic cells"},{"relation":2045,"upstream_event_id":1707,"upstream_event":"Increase, IL-23 from matured dendritic cells","downstream_event_id":1708,"downstream_event":"Th17 cell migration and inflammation induction"},{"relation":2046,"upstream_event_id":1708,"upstream_event":"Th17 cell migration and inflammation induction","downstream_event_id":1709,"downstream_event":"Psoriatic skin disease"}]}