{"id":312,"title":"Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination \u0026 Movement​","short_name":"AChE inhibition - acute mortality via predation","created_at":"2019-12-20T15:55:10.000-05:00","updated_at":"2023-09-25T16:27:01.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":12,"event":"Acetylcholinesterase (AchE) Inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":10,"event":"Acetylcholine accumulation in synapses","event_type":"KeyEvent"},{"event_id":39,"event":"Increased Cholinergic Signaling","event_type":"KeyEvent"},{"event_id":1705,"event":"Impaired coordination and movement","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":2034,"upstream_event_id":12,"upstream_event":"Acetylcholinesterase (AchE) Inhibition","downstream_event_id":10,"downstream_event":"Acetylcholine accumulation in synapses"},{"relation":2039,"upstream_event_id":12,"upstream_event":"Acetylcholinesterase (AchE) Inhibition","downstream_event_id":39,"downstream_event":"Increased Cholinergic Signaling"},{"relation":2035,"upstream_event_id":10,"upstream_event":"Acetylcholine accumulation in synapses","downstream_event_id":39,"downstream_event":"Increased Cholinergic Signaling"},{"relation":2040,"upstream_event_id":12,"upstream_event":"Acetylcholinesterase (AchE) Inhibition","downstream_event_id":1705,"downstream_event":"Impaired coordination and movement"},{"relation":2036,"upstream_event_id":39,"upstream_event":"Increased Cholinergic Signaling","downstream_event_id":1705,"downstream_event":"Impaired coordination and movement"},{"relation":2041,"upstream_event_id":1705,"upstream_event":"Impaired coordination and movement","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"},{"relation":2037,"upstream_event_id":1705,"upstream_event":"Impaired coordination and movement","downstream_event_id":351,"downstream_event":"Increased Mortality"},{"relation":2038,"upstream_event_id":351,"upstream_event":"Increased Mortality","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}