{"id":311,"title":"Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis","short_name":"Energy deposition leading to population decline via DNA oxidation and oocyte apoptosis","created_at":"2019-11-18T04:01:38.000-05:00","updated_at":"2023-09-25T16:27:01.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":273,"stressor_name":"Gamma radiation"}],"aop_mies":[{"event_id":1686,"event":"Deposition of Energy","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":257,"event":"Increase, Reactive Oxygen Species production","event_type":"KeyEvent"},{"event_id":1634,"event":"Increase, Oxidative damage to DNA","event_type":"KeyEvent"},{"event_id":1775,"event":"Increase, Oocyte apoptosis","event_type":"KeyEvent"},{"event_id":1366,"event":"Decrease, Oogenesis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":78,"event":"Reduction, Cumulative fecundity and spawning","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":3000,"upstream_event_id":1686,"upstream_event":"Deposition of Energy","downstream_event_id":257,"downstream_event":"Increase, Reactive Oxygen Species production"},{"relation":3001,"upstream_event_id":257,"upstream_event":"Increase, Reactive Oxygen Species production","downstream_event_id":1634,"downstream_event":"Increase, Oxidative damage to DNA"},{"relation":3002,"upstream_event_id":1634,"upstream_event":"Increase, Oxidative damage to DNA","downstream_event_id":1775,"downstream_event":"Increase, Oocyte apoptosis"},{"relation":3003,"upstream_event_id":1775,"upstream_event":"Increase, Oocyte apoptosis","downstream_event_id":1366,"downstream_event":"Decrease, Oogenesis"},{"relation":3004,"upstream_event_id":1366,"upstream_event":"Decrease, Oogenesis","downstream_event_id":78,"downstream_event":"Reduction, Cumulative fecundity and spawning"},{"relation":3005,"upstream_event_id":78,"upstream_event":"Reduction, Cumulative fecundity and spawning","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}