{"id":309,"title":"Luteinizing hormone receptor antagonism leading to reproductive dysfunction","short_name":"Luteinizing hormone receptor antagonism","created_at":"2019-10-03T10:43:37.000-04:00","updated_at":"2023-09-25T16:27:01.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":505,"stressor_name":"Progesterone,estrogen,melatonin,Letrozole"},{"stressor_id":506,"stressor_name":"glucocorticoids"},{"stressor_id":507,"stressor_name":"Cetrorelix"},{"stressor_id":508,"stressor_name":"Interleukin-6 "}],"aop_mies":[{"event_id":1691,"event":"Antagonism,LH receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1692,"event":"Reduction, Progesterone synthesis","event_type":"KeyEvent"},{"event_id":1693,"event":"Reduction, Plasma progesterone concentration ","event_type":"KeyEvent"},{"event_id":1694,"event":"Reduction, progesterone uptake, decresed maturation ","event_type":"KeyEvent"},{"event_id":1695,"event":"Impaired ovulation","event_type":"KeyEvent"},{"event_id":1696,"event":"Decrease of egg production and cummulative fecundity","event_type":"KeyEvent"}],"aop_aos":[{"event_id":679,"event":"Decline, Population trajectory","event_type":"AdverseOutcome"}],"relationships":[{"relation":1998,"upstream_event_id":1691,"upstream_event":"Antagonism,LH receptor","downstream_event_id":1692,"downstream_event":"Reduction, Progesterone synthesis"},{"relation":1999,"upstream_event_id":1692,"upstream_event":"Reduction, Progesterone synthesis","downstream_event_id":1693,"downstream_event":"Reduction, Plasma progesterone concentration "},{"relation":2000,"upstream_event_id":1693,"upstream_event":"Reduction, Plasma progesterone concentration ","downstream_event_id":1694,"downstream_event":"Reduction, progesterone uptake, decresed maturation "},{"relation":2001,"upstream_event_id":1694,"upstream_event":"Reduction, progesterone uptake, decresed maturation ","downstream_event_id":1695,"downstream_event":"Impaired ovulation"},{"relation":2002,"upstream_event_id":1695,"upstream_event":"Impaired ovulation","downstream_event_id":1696,"downstream_event":"Decrease of egg production and cummulative fecundity"},{"relation":2003,"upstream_event_id":1696,"upstream_event":"Decrease of egg production and cummulative fecundity","downstream_event_id":679,"downstream_event":"Decline, Population trajectory"}]}