{"id":307,"title":"Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring","short_name":"Decreased testosterone synthesis leading to short AGD","created_at":"2019-08-30T04:36:36.000-04:00","updated_at":"2023-09-25T16:27:01.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":14,"stressor_name":"Dibutyl phthalate"},{"stressor_id":11,"stressor_name":"Bis(2-ethylhexyl) phthalate"}],"aop_mies":[],"aop_kes":[{"event_id":413,"event":"Reduction, Testosterone synthesis in Leydig cells","event_type":"KeyEvent"},{"event_id":1690,"event":"Decrease, testosterone levels ","event_type":"KeyEvent"},{"event_id":1613,"event":"Decrease, dihydrotestosterone (DHT) level","event_type":"KeyEvent"},{"event_id":1614,"event":"Decrease, androgen receptors (AR) activation","event_type":"KeyEvent"},{"event_id":286,"event":"Altered, Transcription of genes by AR","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1688,"event":"anogenital distance (AGD), decreased","event_type":"AdverseOutcome"}],"relationships":[{"relation":2198,"upstream_event_id":413,"upstream_event":"Reduction, Testosterone synthesis in Leydig cells","downstream_event_id":1690,"downstream_event":"Decrease, testosterone levels "},{"relation":2211,"upstream_event_id":1690,"upstream_event":"Decrease, testosterone levels ","downstream_event_id":1614,"downstream_event":"Decrease, androgen receptors (AR) activation"},{"relation":2199,"upstream_event_id":1690,"upstream_event":"Decrease, testosterone levels ","downstream_event_id":1613,"downstream_event":"Decrease, dihydrotestosterone (DHT) level"},{"relation":2200,"upstream_event_id":1613,"upstream_event":"Decrease, dihydrotestosterone (DHT) level","downstream_event_id":1614,"downstream_event":"Decrease, androgen receptors (AR) activation"},{"relation":2201,"upstream_event_id":1614,"upstream_event":"Decrease, androgen receptors (AR) activation","downstream_event_id":286,"downstream_event":"Altered, Transcription of genes by AR"},{"relation":2202,"upstream_event_id":286,"upstream_event":"Altered, Transcription of genes by AR","downstream_event_id":1688,"downstream_event":"anogenital distance (AGD), decreased"},{"relation":3310,"upstream_event_id":1614,"upstream_event":"Decrease, androgen receptors (AR) activation","downstream_event_id":1688,"downstream_event":"anogenital distance (AGD), decreased"}]}