{"id":305,"title":"5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring","short_name":"5α-reductase inhibition leading to short AGD","created_at":"2019-08-30T04:02:04.000-04:00","updated_at":"2023-09-25T16:27:00.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":145,"stressor_name":"Finasteride"}],"aop_mies":[{"event_id":1617,"event":"Inhibition, 5α-reductase","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1613,"event":"Decrease, dihydrotestosterone (DHT) level","event_type":"KeyEvent"},{"event_id":1614,"event":"Decrease, androgen receptors (AR) activation","event_type":"KeyEvent"},{"event_id":286,"event":"Altered, Transcription of genes by AR","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1688,"event":"anogenital distance (AGD), decreased","event_type":"AdverseOutcome"}],"relationships":[{"relation":2203,"upstream_event_id":1617,"upstream_event":"Inhibition, 5α-reductase","downstream_event_id":1613,"downstream_event":"Decrease, dihydrotestosterone (DHT) level"},{"relation":3308,"upstream_event_id":1614,"upstream_event":"Decrease, androgen receptors (AR) activation","downstream_event_id":1688,"downstream_event":"anogenital distance (AGD), decreased"},{"relation":2334,"upstream_event_id":1613,"upstream_event":"Decrease, dihydrotestosterone (DHT) level","downstream_event_id":1614,"downstream_event":"Decrease, androgen receptors (AR) activation"}]}