Inhibition, TBX1

All-trans retinoic acid

2022-02-15T10:43:46

Inhibition, TBX1

Molecular

AOPWiki 2019-08-13T00:34:07

2019-08-13T00:34:07

Disruption, Neural crest cell migration

Cellular

AOPWiki 2019-08-13T00:50:35

2019-08-13T00:50:35

Disruption, Progenitor cells of second heart field

Cellular

The first heart field (FHF) and second heart field (SHF) can be distinguished in the cardiac crescent and reside in a horseshoe shaped form (Brade et al., 2018). The SHF cells will stay in a proliferative state until they enter the heart tube to differentiate (Brade et al., 2018). The SHF promotes heart tube elongation at the venous and arterial poles and contributes to the sub pulmonary myocardium (el Robrini et al., 2016; S. Wang & Moise, 2019). The SHF will contribute to the right ventricle and outflow tract (Carlson, 2018). The SHF progenitors facilitate development of the outflow tract, atrium and right ventricle (S. Wang & Moise, 2019). The SHF contributes to the distal myocardium of the OFT and the mesodermal part of great vessel smooth muscles (Buckingham et al., 2005; Choudhary et al., 2009; Dyer & Kirby, 2009). The anterior heart field (AHF) within the SHF gives rise to the OFT and the right ventricle (Kelly et al., 2001; Meilhac et al., 2004; Zaffran et al., 2004). Mef2c positive cells are specific to the AHF (Dodou et al., 2004; Verzi et al., 2005). The AHF requires hedgehog (Hh) signaling from the pharyngeal endoderm for OFT septation but not for OFT elongation (Goddeeris et al., 2007).

Brade, T., Pane, L. S., Moretti, A., Chien, K. R., & Laugwitz, K.-L. (2018). Embryonic Heart Progenitors and Cardiogenesis. 1–18. https://doi.org/10.1101/cshperspect.a013847 Buckingham, M., Meilhac, S., & Zaffran, S. (2005). Building the mammalian heart from two sources of myocardial cells. Nature Reviews. Genetics, 6(11), 826–835. https://doi.org/10.1038/NRG1710 Carlson, B. M. (2018). Human Embryology and Developmental biology E-book. https://books.google.com/books?hl=nl&lr=&id=iyx6DwAAQBAJ&oi=fnd&pg=PP1&dq=carlson+human+embryology&ots=ZCgJJZr-17&sig=LXSoOfaYSNJLoFYaiiJHeqrNyw4 Choudhary, B., Zhou, J., Li, P., Thomas, S., Kaartinen, V., & Sucov, H. M. (2009). Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis (New York, N.Y. : 2000), 47(2), 115–121. https://doi.org/10.1002/DVG.20466 Dodou, E., Verzi, M. P., Anderson, J. P., Xu, S. M., & Black, B. L. (2004). Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development (Cambridge, England), 131(16), 3931–3942. https://doi.org/10.1242/DEV.01256 Dyer, L. A., & Kirby, M. L. (2009). The role of secondary heart field in cardiac development. Developmental Biology, 336(2), 137–144. https://doi.org/10.1016/J.YDBIO.2009.10.009 el Robrini, N., Etchevers, H. C., Ryckebüsch, L., Faure, E., Eudes, N., Niederreither, K., Zaffran, S., & Bertrand, N. (2016). Cardiac outflow morphogenesis depends on effects of retinoic acid signaling on multiple cell lineages. Developmental Dynamics, 245(3), 388–401. https://doi.org/10.1002/dvdy.24357 Goddeeris, M. M., Schwartz, R., Klingensmith, J., & Meyers, E. N. (2007). Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. Development (Cambridge, England), 134(8), 1593–1604. https://doi.org/10.1242/DEV.02824 Kelly, R. G., Brown, N. A., & Buckingham, M. E. (2001). The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Developmental Cell, 1(3), 435–440. https://doi.org/10.1016/S1534-5807(01)00040-5 Meilhac, S. M., Esner, M., Kelly, R. G., Nicolas, J. F., & Buckingham, M. E. (2004). The clonal origin of myocardial cells in different regions of the embryonic mouse heart. Developmental Cell, 6(5), 685–698. https://doi.org/10.1016/S1534-5807(04)00133-9 Verzi, M. P., McCulley, D. J., de Val, S., Dodou, E., & Black, B. L. (2005). The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Developmental Biology, 287(1), 134–145. https://doi.org/10.1016/J.YDBIO.2005.08.041 Wang, S., & Moise, A. R. (2019). Recent insights on the role and regulation of retinoic acid signaling during epicardial development. Genesis, 57(7). https://doi.org/10.1002/dvg.23303 Zaffran, S., Kelly, R. G., Meilhac, S. M., Buckingham, M. E., & Brown, N. A. (2004). Right ventricular myocardium derives from the anterior heart field. Circulation Research, 95(3), 261–268. https://doi.org/10.1161/01.RES.0000136815.73623.BE AOPWiki 2019-08-13T00:51:42

2022-02-15T10:39:17

Impairment, Fourth pharyngeal arch development

Tissue

AOPWiki 2019-08-13T00:53:35

2019-08-13T00:53:35

Abnormalities, Cardiac outflow tract formation

Organ

AOPWiki 2019-08-13T00:54:34

2019-08-13T00:54:34

Anomalies, Congenital cardiac conotruncal

Individual

AOPWiki 2019-08-13T00:56:30

2019-08-13T00:56:30

TBX1 inhibition leading to congenital cardiac conotruncal anomalies

Agnes Aggy

Jinsoo Lee, Korea Institute of Toxicology Wook-Joon Yu, Korea Institute of Toxicology Ji-Seong Jeong, Korea Institute of Toxicology Jung-Hwa Oh, Korea Institute of Toxicology

2.0

AOPWiki 2019-08-06T03:03:26

2023-09-25T16:27:00