{"id":30,"title":"Estrogen receptor antagonism leading to reproductive dysfunction","short_name":"Estrogen receptor antagonism leading to reproductive dysfunction","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:45.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":112,"event":"Antagonism, Estrogen receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":285,"event":"Reduction, Vitellogenin synthesis in liver","event_type":"KeyEvent"},{"event_id":221,"event":"Reduction, Plasma vitellogenin concentrations","event_type":"KeyEvent"},{"event_id":309,"event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development","event_type":"KeyEvent"},{"event_id":78,"event":"Reduction, Cumulative fecundity and spawning","event_type":"KeyEvent"}],"aop_aos":[{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":146,"upstream_event_id":112,"upstream_event":"Antagonism, Estrogen receptor","downstream_event_id":285,"downstream_event":"Reduction, Vitellogenin synthesis in liver"},{"relation":147,"upstream_event_id":285,"upstream_event":"Reduction, Vitellogenin synthesis in liver","downstream_event_id":221,"downstream_event":"Reduction, Plasma vitellogenin concentrations"},{"relation":148,"upstream_event_id":221,"upstream_event":"Reduction, Plasma vitellogenin concentrations","downstream_event_id":309,"downstream_event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development"},{"relation":149,"upstream_event_id":309,"upstream_event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development","downstream_event_id":78,"downstream_event":"Reduction, Cumulative fecundity and spawning"},{"relation":150,"upstream_event_id":78,"upstream_event":"Reduction, Cumulative fecundity and spawning","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}