{"id":297,"title":"Inhibition of retinaldehyde dehydrogenase leads to population decline","short_name":"retinaldehyde dehydrogenase inhibition,population decline","created_at":"2019-05-22T04:45:03.000-04:00","updated_at":"2023-09-25T16:27:00.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":461,"stressor_name":"Disulphiram"},{"stressor_id":462,"stressor_name":"Diethylaminobenzaldehyde"},{"stressor_id":463,"stressor_name":"Citral"},{"stressor_id":464,"stressor_name":"Paclobutrazol"},{"stressor_id":465,"stressor_name":"nitrofen"},{"stressor_id":466,"stressor_name":"4-biphenyl carboxylic acid"},{"stressor_id":467,"stressor_name":"Bisdiamine"},{"stressor_id":468,"stressor_name":"SB-210661"}],"aop_mies":[{"event_id":1637,"event":"Retinaldehyde dehydrogenase inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1640,"event":"Altered, Photoreceptor patterning","event_type":"KeyEvent"},{"event_id":1641,"event":"Decreased retinoic acid (RA) synthesis","event_type":"KeyEvent"},{"event_id":1642,"event":"Decreased plasma RA level","event_type":"KeyEvent"},{"event_id":1643,"event":"Altered, Visual function","event_type":"KeyEvent"}],"aop_aos":[{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":1908,"upstream_event_id":1637,"upstream_event":"Retinaldehyde dehydrogenase inhibition","downstream_event_id":1641,"downstream_event":"Decreased retinoic acid (RA) synthesis"},{"relation":1909,"upstream_event_id":1641,"upstream_event":"Decreased retinoic acid (RA) synthesis","downstream_event_id":1642,"downstream_event":"Decreased plasma RA level"},{"relation":1910,"upstream_event_id":1642,"upstream_event":"Decreased plasma RA level","downstream_event_id":1640,"downstream_event":"Altered, Photoreceptor patterning"},{"relation":2228,"upstream_event_id":1640,"upstream_event":"Altered, Photoreceptor patterning","downstream_event_id":1643,"downstream_event":"Altered, Visual function"},{"relation":2229,"upstream_event_id":1643,"upstream_event":"Altered, Visual function","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}