{"id":29,"title":"Estrogen receptor agonism leading to reproductive dysfunction","short_name":"Estrogen receptor agonism leading to reproductive dysfunction","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:45.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":111,"event":"Agonism, Estrogen receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":78,"event":"Reduction, Cumulative fecundity and spawning","event_type":"KeyEvent"},{"event_id":220,"event":"Increase, Plasma vitellogenin concentrations","event_type":"KeyEvent"},{"event_id":307,"event":"Increase, Vitellogenin synthesis in liver","event_type":"KeyEvent"},{"event_id":252,"event":"Increase, Renal pathology due to VTG deposition","event_type":"KeyEvent"}],"aop_aos":[{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"},{"event_id":363,"event":"Altered, Reproductive behaviour","event_type":"AdverseOutcome"},{"event_id":339,"event":"Altered, Larval development","event_type":"AdverseOutcome"},{"event_id":364,"event":"Impaired development of, Reproductive organs","event_type":"AdverseOutcome"}],"relationships":[{"relation":50,"upstream_event_id":111,"upstream_event":"Agonism, Estrogen receptor","downstream_event_id":364,"downstream_event":"Impaired development of, Reproductive organs"},{"relation":51,"upstream_event_id":252,"upstream_event":"Increase, Renal pathology due to VTG deposition","downstream_event_id":339,"downstream_event":"Altered, Larval development"},{"relation":52,"upstream_event_id":111,"upstream_event":"Agonism, Estrogen receptor","downstream_event_id":307,"downstream_event":"Increase, Vitellogenin synthesis in liver"},{"relation":53,"upstream_event_id":220,"upstream_event":"Increase, Plasma vitellogenin concentrations","downstream_event_id":252,"downstream_event":"Increase, Renal pathology due to VTG deposition"},{"relation":54,"upstream_event_id":111,"upstream_event":"Agonism, Estrogen receptor","downstream_event_id":363,"downstream_event":"Altered, Reproductive behaviour"},{"relation":55,"upstream_event_id":307,"upstream_event":"Increase, Vitellogenin synthesis in liver","downstream_event_id":220,"downstream_event":"Increase, Plasma vitellogenin concentrations"}]}