{"id":288,"title":"Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)","short_name":"Cyp17A1 inhibition leads to undescended testes in mammals","created_at":"2019-04-10T04:22:51.000-04:00","updated_at":"2023-09-25T16:26:59.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1609,"event":"Inhibition, Cytochrome P450 enzyme (CYP17A1) activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1610,"event":"Reduction, 17-OH-pregnenolone conversion in DHEA","event_type":"KeyEvent"},{"event_id":1611,"event":"Reduction, 17-OH-progesterone conversion in androstenedione","event_type":"KeyEvent"},{"event_id":1612,"event":"Decrease, testosterone synthesis/level","event_type":"KeyEvent"},{"event_id":1613,"event":"Decrease, dihydrotestosterone (DHT) level","event_type":"KeyEvent"},{"event_id":1614,"event":"Decrease, androgen receptors (AR) activation","event_type":"KeyEvent"},{"event_id":1615,"event":"Impaired inguinoscrotal testicular descent phase","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1616,"event":"Malformation, cryptorchidism - maldescended testis","event_type":"AdverseOutcome"}],"relationships":[{"relation":1839,"upstream_event_id":1609,"upstream_event":"Inhibition, Cytochrome P450 enzyme (CYP17A1) activity","downstream_event_id":1610,"downstream_event":"Reduction, 17-OH-pregnenolone conversion in DHEA"},{"relation":1840,"upstream_event_id":1609,"upstream_event":"Inhibition, Cytochrome P450 enzyme (CYP17A1) activity","downstream_event_id":1611,"downstream_event":"Reduction, 17-OH-progesterone conversion in androstenedione"},{"relation":1928,"upstream_event_id":1610,"upstream_event":"Reduction, 17-OH-pregnenolone conversion in DHEA","downstream_event_id":1612,"downstream_event":"Decrease, testosterone synthesis/level"},{"relation":1929,"upstream_event_id":1611,"upstream_event":"Reduction, 17-OH-progesterone conversion in androstenedione","downstream_event_id":1612,"downstream_event":"Decrease, testosterone synthesis/level"},{"relation":1930,"upstream_event_id":1612,"upstream_event":"Decrease, testosterone synthesis/level","downstream_event_id":1613,"downstream_event":"Decrease, dihydrotestosterone (DHT) level"},{"relation":1931,"upstream_event_id":1613,"upstream_event":"Decrease, dihydrotestosterone (DHT) level","downstream_event_id":1614,"downstream_event":"Decrease, androgen receptors (AR) activation"},{"relation":1932,"upstream_event_id":1612,"upstream_event":"Decrease, testosterone synthesis/level","downstream_event_id":1614,"downstream_event":"Decrease, androgen receptors (AR) activation"},{"relation":1933,"upstream_event_id":1614,"upstream_event":"Decrease, androgen receptors (AR) activation","downstream_event_id":1615,"downstream_event":"Impaired inguinoscrotal testicular descent phase"},{"relation":1934,"upstream_event_id":1615,"upstream_event":"Impaired inguinoscrotal testicular descent phase","downstream_event_id":1616,"downstream_event":"Malformation, cryptorchidism - maldescended testis"}]}