{"id":282,"title":"Adverse outcome pathway on photochemical toxicity initiated by light exposure","short_name":"ROS-mediated chemical phototoxicity","created_at":"2019-02-03T00:29:48.000-05:00","updated_at":"2023-09-25T16:26:59.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":415,"stressor_name":"Light (290-700 nm)"},{"stressor_id":440,"stressor_name":"Photoreactive chemicals"},{"stressor_id":303,"stressor_name":"Reactive oxygen species"}],"aop_mies":[{"event_id":1592,"event":"ROS generation from photoactivated chemicals","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1594,"event":"Oxidation of membrane lipids","event_type":"KeyEvent"},{"event_id":1595,"event":"Oxidation/denatuation of membrane proteins","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1599,"event":"Inflamatory events in light-exposed tissues","event_type":"AdverseOutcome"}],"relationships":[{"relation":1784,"upstream_event_id":1592,"upstream_event":"ROS generation from photoactivated chemicals","downstream_event_id":1594,"downstream_event":"Oxidation of membrane lipids"},{"relation":1785,"upstream_event_id":1592,"upstream_event":"ROS generation from photoactivated chemicals","downstream_event_id":1595,"downstream_event":"Oxidation/denatuation of membrane proteins"},{"relation":1796,"upstream_event_id":1594,"upstream_event":"Oxidation of membrane lipids","downstream_event_id":1599,"downstream_event":"Inflamatory events in light-exposed tissues"},{"relation":1797,"upstream_event_id":1595,"upstream_event":"Oxidation/denatuation of membrane proteins","downstream_event_id":1599,"downstream_event":"Inflamatory events in light-exposed tissues"}]}