{"id":281,"title":"Acetylcholinesterase Inhibition Leading to Neurodegeneration","short_name":"AChE Inhibition Leading to Neurodegeneration","created_at":"2019-01-30T12:36:17.000-05:00","updated_at":"2023-09-25T16:26:59.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":12,"event":"Acetylcholinesterase (AchE) Inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":10,"event":"Acetylcholine accumulation in synapses","event_type":"KeyEvent"},{"event_id":1602,"event":"Activation, Muscarinic Acetylcholine Receptors","event_type":"KeyEvent"},{"event_id":1623,"event":"Occurrence, Focal Seizure","event_type":"KeyEvent"},{"event_id":1350,"event":"Increased, glutamate","event_type":"KeyEvent"},{"event_id":388,"event":"Overactivation, NMDARs","event_type":"KeyEvent"},{"event_id":1788,"event":"Status epilepticus","event_type":"KeyEvent"},{"event_id":389,"event":"Increased, Intracellular Calcium overload","event_type":"KeyEvent"},{"event_id":55,"event":"Cell injury/death","event_type":"KeyEvent"}],"aop_aos":[{"event_id":352,"event":"N/A, Neurodegeneration","event_type":"AdverseOutcome"}],"relationships":[{"relation":1801,"upstream_event_id":12,"upstream_event":"Acetylcholinesterase (AchE) Inhibition","downstream_event_id":10,"downstream_event":"Acetylcholine accumulation in synapses"},{"relation":1803,"upstream_event_id":10,"upstream_event":"Acetylcholine accumulation in synapses","downstream_event_id":1602,"downstream_event":"Activation, Muscarinic Acetylcholine Receptors"},{"relation":1855,"upstream_event_id":1602,"upstream_event":"Activation, Muscarinic Acetylcholine Receptors","downstream_event_id":1623,"downstream_event":"Occurrence, Focal Seizure"},{"relation":3250,"upstream_event_id":1623,"upstream_event":"Occurrence, Focal Seizure","downstream_event_id":1350,"downstream_event":"Increased, glutamate"},{"relation":3251,"upstream_event_id":1350,"upstream_event":"Increased, glutamate","downstream_event_id":388,"downstream_event":"Overactivation, NMDARs"},{"relation":3249,"upstream_event_id":388,"upstream_event":"Overactivation, NMDARs","downstream_event_id":1788,"downstream_event":"Status epilepticus"},{"relation":3252,"upstream_event_id":1788,"upstream_event":"Status epilepticus","downstream_event_id":1350,"downstream_event":"Increased, glutamate"},{"relation":1802,"upstream_event_id":388,"upstream_event":"Overactivation, NMDARs","downstream_event_id":389,"downstream_event":"Increased, Intracellular Calcium overload"},{"relation":3253,"upstream_event_id":1788,"upstream_event":"Status epilepticus","downstream_event_id":389,"downstream_event":"Increased, Intracellular Calcium overload"},{"relation":1808,"upstream_event_id":389,"upstream_event":"Increased, Intracellular Calcium overload","downstream_event_id":55,"downstream_event":"Cell injury/death"},{"relation":2124,"upstream_event_id":55,"upstream_event":"Cell injury/death","downstream_event_id":352,"downstream_event":"N/A, Neurodegeneration"}]}