{"id":280,"title":"α-diketone-induced bronchiolitis obliterans","short_name":"α-diketone-induced bronchiolitis obliterans","created_at":"2019-01-30T09:26:02.000-05:00","updated_at":"2023-09-25T16:26:59.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1584,"event":"Interaction of α-diketones with arginine residues","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1585,"event":"Proteasomal dysfunction","event_type":"KeyEvent"},{"event_id":1586,"event":"Airway epithelial injury","event_type":"KeyEvent"},{"event_id":149,"event":"Increase, Inflammation","event_type":"KeyEvent"},{"event_id":1457,"event":"Induction, Epithelial Mesenchymal Transition","event_type":"KeyEvent"},{"event_id":1587,"event":"Fibroproliferative airway lesions","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1588,"event":"Bronchiolitis obliterans","event_type":"AdverseOutcome"}],"relationships":[{"relation":1772,"upstream_event_id":1584,"upstream_event":"Interaction of α-diketones with arginine residues","downstream_event_id":1585,"downstream_event":"Proteasomal dysfunction"},{"relation":1773,"upstream_event_id":1585,"upstream_event":"Proteasomal dysfunction","downstream_event_id":1586,"downstream_event":"Airway epithelial injury"},{"relation":1774,"upstream_event_id":1586,"upstream_event":"Airway epithelial injury","downstream_event_id":149,"downstream_event":"Increase, Inflammation"},{"relation":1775,"upstream_event_id":149,"upstream_event":"Increase, Inflammation","downstream_event_id":1457,"downstream_event":"Induction, Epithelial Mesenchymal Transition"},{"relation":1776,"upstream_event_id":149,"upstream_event":"Increase, Inflammation","downstream_event_id":1587,"downstream_event":"Fibroproliferative airway lesions"},{"relation":1777,"upstream_event_id":1457,"upstream_event":"Induction, Epithelial Mesenchymal Transition","downstream_event_id":1587,"downstream_event":"Fibroproliferative airway lesions"},{"relation":1778,"upstream_event_id":1587,"upstream_event":"Fibroproliferative airway lesions","downstream_event_id":1588,"downstream_event":"Bronchiolitis obliterans"}]}