{"id":28,"title":"Cyclooxygenase inhibition leading reproductive failure","short_name":"Cyclooxygenase inhibition leading reproductive failure","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:45.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":79,"event":"Inhibition, Cyclooxygenase activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":243,"event":"Reduction, Prostaglandin E2 concentration","event_type":"KeyEvent"},{"event_id":49,"event":"Reduction, Ca and HCO3 transport to shell gland","event_type":"KeyEvent"},{"event_id":106,"event":"Reduction, Eggshell thickness","event_type":"KeyEvent"},{"event_id":119,"event":"N/A, Gap","event_type":"KeyEvent"}],"aop_aos":[{"event_id":253,"event":"N/A, Reproductive failure","event_type":"AdverseOutcome"}],"relationships":[{"relation":45,"upstream_event_id":79,"upstream_event":"Inhibition, Cyclooxygenase activity","downstream_event_id":243,"downstream_event":"Reduction, Prostaglandin E2 concentration"},{"relation":46,"upstream_event_id":243,"upstream_event":"Reduction, Prostaglandin E2 concentration","downstream_event_id":119,"downstream_event":"N/A, Gap"},{"relation":47,"upstream_event_id":119,"upstream_event":"N/A, Gap","downstream_event_id":49,"downstream_event":"Reduction, Ca and HCO3 transport to shell gland"},{"relation":48,"upstream_event_id":49,"upstream_event":"Reduction, Ca and HCO3 transport to shell gland","downstream_event_id":106,"downstream_event":"Reduction, Eggshell thickness"},{"relation":49,"upstream_event_id":106,"upstream_event":"Reduction, Eggshell thickness","downstream_event_id":253,"downstream_event":"N/A, Reproductive failure"}]}