{"id":278,"title":"IKK complex inhibition leading to liver injury","short_name":"IKK complex inhibition leading to liver injury","created_at":"2019-01-07T08:00:15.000-05:00","updated_at":"2023-09-25T16:26:59.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1574,"event":"Inhibition, IKK complex","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":202,"event":"Inhibition, Nuclear factor kappa B (NF-kB)","event_type":"KeyEvent"},{"event_id":1575,"event":"Activation, Caspase 8 pathway","event_type":"KeyEvent"},{"event_id":55,"event":"Cell injury/death","event_type":"KeyEvent"},{"event_id":1576,"event":"Activation, Tissue resident cells (Kuppfer cells)","event_type":"KeyEvent"},{"event_id":1579,"event":"Increase, proinflammatory mediators (TNFalpha)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1548,"event":"Necrotic Tissue","event_type":"AdverseOutcome"},{"event_id":1549,"event":"Liver Injury","event_type":"AdverseOutcome"}],"relationships":[{"relation":1759,"upstream_event_id":1574,"upstream_event":"Inhibition, IKK complex","downstream_event_id":202,"downstream_event":"Inhibition, Nuclear factor kappa B (NF-kB)"},{"relation":1767,"upstream_event_id":55,"upstream_event":"Cell injury/death","downstream_event_id":1576,"downstream_event":"Activation, Tissue resident cells (Kuppfer cells)"},{"relation":1760,"upstream_event_id":202,"upstream_event":"Inhibition, Nuclear factor kappa B (NF-kB)","downstream_event_id":1575,"downstream_event":"Activation, Caspase 8 pathway"},{"relation":1761,"upstream_event_id":1575,"upstream_event":"Activation, Caspase 8 pathway","downstream_event_id":55,"downstream_event":"Cell injury/death"},{"relation":1765,"upstream_event_id":55,"upstream_event":"Cell injury/death","downstream_event_id":1548,"downstream_event":"Necrotic Tissue"},{"relation":1766,"upstream_event_id":1548,"upstream_event":"Necrotic Tissue","downstream_event_id":1549,"downstream_event":"Liver Injury"},{"relation":1768,"upstream_event_id":1576,"upstream_event":"Activation, Tissue resident cells (Kuppfer cells)","downstream_event_id":1579,"downstream_event":"Increase, proinflammatory mediators (TNFalpha)"}]}