{"id":277,"title":"Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response","short_name":"Impaired IL-1R1 signaling leading to impairment of TDAR","created_at":"2018-12-20T20:02:52.000-05:00","updated_at":"2023-09-25T16:26:59.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":489,"stressor_name":"IL-1 receptor antagonist（IL-1Ra）(Anakinra)"},{"stressor_id":490,"stressor_name":"anti-IL-1b antibody (Canakinumab)"},{"stressor_id":491,"stressor_name":"soluble IL-1R (Rilonacept)"},{"stressor_id":518,"stressor_name":"anti-IL-1b antibody (Gevokizumab)"},{"stressor_id":492,"stressor_name":"Dexamethasone"},{"stressor_id":486,"stressor_name":"minocycline"},{"stressor_id":609,"stressor_name":"Belnacasan (VX-765)"},{"stressor_id":611,"stressor_name":"Pralnacasan (VX-740, HMR3480)"},{"stressor_id":488,"stressor_name":"cinnamic aldehyde"},{"stressor_id":637,"stressor_name":"Dimethyl fumarate"},{"stressor_id":612,"stressor_name":"curcumin"},{"stressor_id":614,"stressor_name":"iguratimod"},{"stressor_id":638,"stressor_name":"(-)-Epigallocatechin gallate"},{"stressor_id":616,"stressor_name":"TAK-242"},{"stressor_id":617,"stressor_name":"IRAK4 inhibitors"},{"stressor_id":636,"stressor_name":"Dehydroxymethylepoxyquinomicin (DHMEQ)"}],"aop_mies":[{"event_id":1700,"event":"Impaired IL-1R1 signaling in T cell","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":202,"event":"Inhibition, Nuclear factor kappa B (NF-kB)","event_type":"KeyEvent"},{"event_id":1702,"event":"Suppression of  T cell activation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":984,"event":"Impairment, T-cell dependent antibody response","event_type":"AdverseOutcome"}],"relationships":[{"relation":2024,"upstream_event_id":1700,"upstream_event":"Impaired IL-1R1 signaling in T cell","downstream_event_id":202,"downstream_event":"Inhibition, Nuclear factor kappa B (NF-kB)"},{"relation":2025,"upstream_event_id":202,"upstream_event":"Inhibition, Nuclear factor kappa B (NF-kB)","downstream_event_id":1702,"downstream_event":"Suppression of  T cell activation"},{"relation":3476,"upstream_event_id":1702,"upstream_event":"Suppression of  T cell activation","downstream_event_id":984,"downstream_event":"Impairment, T-cell dependent antibody response"}]}