{"id":275,"title":"Histone deacetylase inhibition leads to neural tube defects","short_name":"HDAC inhibition leads to neural tube defects","created_at":"2018-12-20T08:24:47.000-05:00","updated_at":"2023-09-25T16:26:58.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1502,"event":"Histone deacetylase inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1503,"event":"Histone acetylation, increase","event_type":"KeyEvent"},{"event_id":1239,"event":"Altered, Gene Expression","event_type":"KeyEvent"},{"event_id":1560,"event":"Altered differentiation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1561,"event":"Neural tube defects","event_type":"AdverseOutcome"}],"relationships":[{"relation":1736,"upstream_event_id":1502,"upstream_event":"Histone deacetylase inhibition","downstream_event_id":1503,"downstream_event":"Histone acetylation, increase"},{"relation":1737,"upstream_event_id":1503,"upstream_event":"Histone acetylation, increase","downstream_event_id":1239,"downstream_event":"Altered, Gene Expression"},{"relation":1738,"upstream_event_id":1239,"upstream_event":"Altered, Gene Expression","downstream_event_id":1560,"downstream_event":"Altered differentiation"},{"relation":1739,"upstream_event_id":1560,"upstream_event":"Altered differentiation","downstream_event_id":1561,"downstream_event":"Neural tube defects"}]}