{"id":273,"title":"Mitochondrial complex inhibition leading to liver injury","short_name":"Mitochondrial complex inhibition leading to liver injury","created_at":"2018-12-19T09:14:24.000-05:00","updated_at":"2023-09-25T16:26:58.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1542,"event":"Increase, Mitochondrial complex III antagonism","event_type":"MolecularInitiatingEvent"},{"event_id":1543,"event":"Mitochondrial Complex IV inhibition","event_type":"MolecularInitiatingEvent"},{"event_id":1544,"event":"Mitochondrial Complex V inhibition","event_type":"MolecularInitiatingEvent"},{"event_id":888,"event":"Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)","event_type":"MolecularInitiatingEvent"},{"event_id":887,"event":"Inhibition, NADH-ubiquinone oxidoreductase  (complex I)","event_type":"MolecularInitiatingEvent"},{"event_id":1653,"event":"Binding of inhibitor to mitochondrial complex III","event_type":"MolecularInitiatingEvent"},{"event_id":1654,"event":"Binding of inhibitor to mitochondrial complex IV","event_type":"MolecularInitiatingEvent"},{"event_id":1655,"event":"Binding of inhibitor to mitochondrial complex V","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1545,"event":"Decrease in mitochondrial oxidative phosphorylation","event_type":"KeyEvent"},{"event_id":1546,"event":"Increased reactive oxygen species (in the mitochondria)","event_type":"KeyEvent"},{"event_id":1547,"event":"Mitochondrial Injury","event_type":"KeyEvent"},{"event_id":889,"event":"Impaired, Proteostasis","event_type":"KeyEvent"},{"event_id":55,"event":"Cell injury/death","event_type":"KeyEvent"},{"event_id":177,"event":"N/A, Mitochondrial dysfunction 1","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1548,"event":"Necrotic Tissue","event_type":"AdverseOutcome"},{"event_id":1549,"event":"Liver Injury","event_type":"AdverseOutcome"}],"relationships":[{"relation":1714,"upstream_event_id":1542,"upstream_event":"Increase, Mitochondrial complex III antagonism","downstream_event_id":1545,"downstream_event":"Decrease in mitochondrial oxidative phosphorylation"},{"relation":1715,"upstream_event_id":1543,"upstream_event":"Mitochondrial Complex IV inhibition","downstream_event_id":1545,"downstream_event":"Decrease in mitochondrial oxidative phosphorylation"},{"relation":1716,"upstream_event_id":1544,"upstream_event":"Mitochondrial Complex V inhibition","downstream_event_id":1545,"downstream_event":"Decrease in mitochondrial oxidative phosphorylation"},{"relation":1711,"upstream_event_id":1548,"upstream_event":"Necrotic Tissue","downstream_event_id":1549,"downstream_event":"Liver Injury"},{"relation":1936,"upstream_event_id":888,"upstream_event":"Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)","downstream_event_id":887,"downstream_event":"Inhibition, NADH-ubiquinone oxidoreductase  (complex I)"},{"relation":1937,"upstream_event_id":887,"upstream_event":"Inhibition, NADH-ubiquinone oxidoreductase  (complex I)","downstream_event_id":1545,"downstream_event":"Decrease in mitochondrial oxidative phosphorylation"},{"relation":1940,"upstream_event_id":889,"upstream_event":"Impaired, Proteostasis","downstream_event_id":55,"downstream_event":"Cell injury/death"},{"relation":1941,"upstream_event_id":55,"upstream_event":"Cell injury/death","downstream_event_id":1548,"downstream_event":"Necrotic Tissue"},{"relation":1942,"upstream_event_id":1653,"upstream_event":"Binding of inhibitor to mitochondrial complex III","downstream_event_id":1542,"downstream_event":"Increase, Mitochondrial complex III antagonism"},{"relation":1943,"upstream_event_id":1654,"upstream_event":"Binding of inhibitor to mitochondrial complex IV","downstream_event_id":1543,"downstream_event":"Mitochondrial Complex IV inhibition"},{"relation":1944,"upstream_event_id":1655,"upstream_event":"Binding of inhibitor to mitochondrial complex V","downstream_event_id":1544,"downstream_event":"Mitochondrial Complex V inhibition"},{"relation":1957,"upstream_event_id":1545,"upstream_event":"Decrease in mitochondrial oxidative phosphorylation","downstream_event_id":177,"downstream_event":"N/A, Mitochondrial dysfunction 1"},{"relation":1958,"upstream_event_id":1546,"upstream_event":"Increased reactive oxygen species (in the mitochondria)","downstream_event_id":177,"downstream_event":"N/A, Mitochondrial dysfunction 1"},{"relation":1959,"upstream_event_id":177,"upstream_event":"N/A, Mitochondrial dysfunction 1","downstream_event_id":1546,"downstream_event":"Increased reactive oxygen species (in the mitochondria)"},{"relation":1960,"upstream_event_id":177,"upstream_event":"N/A, Mitochondrial dysfunction 1","downstream_event_id":889,"downstream_event":"Impaired, Proteostasis"}]}