{"id":266,"title":"Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity","short_name":"Uncoupling of OXPHOS leading to growth inhibition 4","created_at":"2018-05-24T15:31:11.000-04:00","updated_at":"2023-09-25T16:26:58.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1446,"event":"Decrease, Coupling of oxidative phosphorylation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1771,"event":"Decrease, Adenosine triphosphate pool","event_type":"KeyEvent"},{"event_id":1562,"event":"Decreased Na/K ATPase activity","event_type":"KeyEvent"},{"event_id":1527,"event":"Increase, Cell membrane depolarization","event_type":"KeyEvent"},{"event_id":55,"event":"Cell injury/death","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1521,"event":"Decrease, Growth","event_type":"AdverseOutcome"}],"relationships":[{"relation":3256,"upstream_event_id":1446,"upstream_event":"Decrease, Coupling of oxidative phosphorylation","downstream_event_id":1771,"downstream_event":"Decrease, Adenosine triphosphate pool"},{"relation":3257,"upstream_event_id":1771,"upstream_event":"Decrease, Adenosine triphosphate pool","downstream_event_id":1562,"downstream_event":"Decreased Na/K ATPase activity"},{"relation":3258,"upstream_event_id":1562,"upstream_event":"Decreased Na/K ATPase activity","downstream_event_id":1527,"downstream_event":"Increase, Cell membrane depolarization"},{"relation":3259,"upstream_event_id":1527,"upstream_event":"Increase, Cell membrane depolarization","downstream_event_id":55,"downstream_event":"Cell injury/death"},{"relation":3260,"upstream_event_id":55,"upstream_event":"Cell injury/death","downstream_event_id":1521,"downstream_event":"Decrease, Growth"}]}