{"id":261,"title":"L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility","short_name":"L-type calcium channel blockade leading to heart failure via contractility decrease ","created_at":"2018-05-10T08:37:07.000-04:00","updated_at":"2023-09-25T16:26:58.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":380,"stressor_name":"Calcium channel blockers "},{"stressor_id":382,"stressor_name":"Nifedipine"},{"stressor_id":383,"stressor_name":"Amlodipine"},{"stressor_id":384,"stressor_name":"Felodipine"},{"stressor_id":385,"stressor_name":"Nisoldipine"},{"stressor_id":386,"stressor_name":"Nimodipine"},{"stressor_id":387,"stressor_name":"Nitrendipine"},{"stressor_id":388,"stressor_name":"Diltiazem"},{"stressor_id":118,"stressor_name":"Verapamil"}],"aop_mies":[{"event_id":1529,"event":"Blockade, L-Type Calcium Channels ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1530,"event":"Decrease, Calcium currents","event_type":"KeyEvent"},{"event_id":1531,"event":"Decrease, Calcium binding to Troponin C","event_type":"KeyEvent"},{"event_id":1532,"event":"Decrease, Cardiac contractility ","event_type":"KeyEvent"},{"event_id":1533,"event":"Decrease, Cardiac ejection fraction ","event_type":"KeyEvent"},{"event_id":1536,"event":"Disruption, Intracellular calcium mobilization","event_type":"KeyEvent"},{"event_id":1537,"event":"Disruption, Sarcomere assembly","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1535,"event":"Heart failure ","event_type":"AdverseOutcome"}],"relationships":[{"relation":1663,"upstream_event_id":1529,"upstream_event":"Blockade, L-Type Calcium Channels ","downstream_event_id":1530,"downstream_event":"Decrease, Calcium currents"},{"relation":1664,"upstream_event_id":1530,"upstream_event":"Decrease, Calcium currents","downstream_event_id":1531,"downstream_event":"Decrease, Calcium binding to Troponin C"},{"relation":1665,"upstream_event_id":1531,"upstream_event":"Decrease, Calcium binding to Troponin C","downstream_event_id":1532,"downstream_event":"Decrease, Cardiac contractility "},{"relation":1666,"upstream_event_id":1532,"upstream_event":"Decrease, Cardiac contractility ","downstream_event_id":1533,"downstream_event":"Decrease, Cardiac ejection fraction "},{"relation":1667,"upstream_event_id":1533,"upstream_event":"Decrease, Cardiac ejection fraction ","downstream_event_id":1535,"downstream_event":"Heart failure "},{"relation":1668,"upstream_event_id":1530,"upstream_event":"Decrease, Calcium currents","downstream_event_id":1536,"downstream_event":"Disruption, Intracellular calcium mobilization"},{"relation":1669,"upstream_event_id":1536,"upstream_event":"Disruption, Intracellular calcium mobilization","downstream_event_id":1537,"downstream_event":"Disruption, Sarcomere assembly"},{"relation":1670,"upstream_event_id":1537,"upstream_event":"Disruption, Sarcomere assembly","downstream_event_id":1532,"downstream_event":"Decrease, Cardiac contractility "}]}