{"id":26,"title":"Calcium-mediated neuronal ROS production and energy imbalance","short_name":"Calcium-mediated neuronal ROS production and energy imbalance","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:45.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":51,"event":"Inhibition, Ca++ ATPase","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":50,"event":"Increase, Ca++ (intracellular)","event_type":"KeyEvent"},{"event_id":178,"event":"Disruption, Mitochondrial electron transport chain","event_type":"KeyEvent"},{"event_id":40,"event":"Decrease, Mitochondrial ATP production","event_type":"KeyEvent"},{"event_id":257,"event":"Increase, Reactive Oxygen Species production","event_type":"KeyEvent"},{"event_id":193,"event":"Decreased, Nitric Oxide","event_type":"KeyEvent"},{"event_id":166,"event":"Decreased, Long-term potentiation (LTP)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":356,"event":"Increased, Oxidative damage","event_type":"AdverseOutcome"}],"relationships":[{"relation":34,"upstream_event_id":51,"upstream_event":"Inhibition, Ca++ ATPase","downstream_event_id":50,"downstream_event":"Increase, Ca++ (intracellular)"},{"relation":35,"upstream_event_id":50,"upstream_event":"Increase, Ca++ (intracellular)","downstream_event_id":178,"downstream_event":"Disruption, Mitochondrial electron transport chain"},{"relation":36,"upstream_event_id":178,"upstream_event":"Disruption, Mitochondrial electron transport chain","downstream_event_id":40,"downstream_event":"Decrease, Mitochondrial ATP production"},{"relation":37,"upstream_event_id":178,"upstream_event":"Disruption, Mitochondrial electron transport chain","downstream_event_id":257,"downstream_event":"Increase, Reactive Oxygen Species production"},{"relation":38,"upstream_event_id":193,"upstream_event":"Decreased, Nitric Oxide","downstream_event_id":166,"downstream_event":"Decreased, Long-term potentiation (LTP)"},{"relation":39,"upstream_event_id":257,"upstream_event":"Increase, Reactive Oxygen Species production","downstream_event_id":193,"downstream_event":"Decreased, Nitric Oxide"},{"relation":40,"upstream_event_id":257,"upstream_event":"Increase, Reactive Oxygen Species production","downstream_event_id":356,"downstream_event":"Increased, Oxidative damage"}]}