{"id":257,"title":"Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity","short_name":"Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity","created_at":"2017-10-25T08:13:54.000-04:00","updated_at":"2023-09-25T16:26:57.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":327,"stressor_name":"Aminoglycosides"},{"stressor_id":328,"stressor_name":"Gentamicin"},{"stressor_id":329,"stressor_name":"Tobramycin"},{"stressor_id":330,"stressor_name":"Vancomycin"},{"stressor_id":331,"stressor_name":"Polymyxin B"},{"stressor_id":332,"stressor_name":"Colistin"},{"stressor_id":333,"stressor_name":"Albumin"},{"stressor_id":334,"stressor_name":"low molecular weight proteins"},{"stressor_id":335,"stressor_name":"Cadmium"}],"aop_mies":[{"event_id":1486,"event":"Binding of substrate, endocytic receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":831,"event":"Disturbance, Lysosomal function","event_type":"KeyEvent"},{"event_id":898,"event":"Disruption, Lysosome","event_type":"KeyEvent"},{"event_id":709,"event":"Increase, Cytotoxicity (renal tubular cell)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":814,"event":"Occurrence, Kidney toxicity","event_type":"AdverseOutcome"}],"relationships":[{"relation":1555,"upstream_event_id":1486,"upstream_event":"Binding of substrate, endocytic receptor","downstream_event_id":831,"downstream_event":"Disturbance, Lysosomal function"},{"relation":1556,"upstream_event_id":831,"upstream_event":"Disturbance, Lysosomal function","downstream_event_id":898,"downstream_event":"Disruption, Lysosome"},{"relation":1557,"upstream_event_id":898,"upstream_event":"Disruption, Lysosome","downstream_event_id":709,"downstream_event":"Increase, Cytotoxicity (renal tubular cell)"},{"relation":1558,"upstream_event_id":709,"upstream_event":"Increase, Cytotoxicity (renal tubular cell)","downstream_event_id":814,"downstream_event":"Occurrence, Kidney toxicity"}]}