{"id":235,"title":"Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening","short_name":"Serotonin 1A Receptor Agonism to Anti-depressant Activity via K Channel","created_at":"2017-06-23T07:02:54.000-04:00","updated_at":"2023-09-25T16:26:57.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1431,"event":"Serotonin 1A Receptor Agonism","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1426,"event":"Release of G Proteins","event_type":"KeyEvent"},{"event_id":1427,"event":"Opening of G protein gated inward rectifying K channels","event_type":"KeyEvent"},{"event_id":763,"event":"hyperpolarisation, neuron","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1432,"event":"Anti-depressant Activity","event_type":"AdverseOutcome"}],"relationships":[{"relation":1423,"upstream_event_id":1431,"upstream_event":"Serotonin 1A Receptor Agonism","downstream_event_id":1426,"downstream_event":"Release of G Proteins"},{"relation":1424,"upstream_event_id":1426,"upstream_event":"Release of G Proteins","downstream_event_id":1427,"downstream_event":"Opening of G protein gated inward rectifying K channels"},{"relation":1425,"upstream_event_id":1427,"upstream_event":"Opening of G protein gated inward rectifying K channels","downstream_event_id":763,"downstream_event":"hyperpolarisation, neuron"},{"relation":1426,"upstream_event_id":763,"upstream_event":"hyperpolarisation, neuron","downstream_event_id":1432,"downstream_event":"Anti-depressant Activity"}]}