{"id":230,"title":"presynaptic neuron 1 activation to epilepsy","short_name":"presynaptic neuron 1 activation to epilepsy","created_at":"2017-06-02T11:27:37.000-04:00","updated_at":"2023-09-25T16:26:56.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1349,"event":"Activated, presynaptic neuron 1","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1350,"event":"Increased, glutamate","event_type":"KeyEvent"},{"event_id":1351,"event":"Activated, NMDA receptor","event_type":"KeyEvent"},{"event_id":1321,"event":"Increased, intracellular sodium (Na+)","event_type":"KeyEvent"},{"event_id":1352,"event":"Activated, voltage-gated sodium channel","event_type":"KeyEvent"},{"event_id":1354,"event":"Treat, carbamazepine","event_type":"KeyEvent"},{"event_id":1353,"event":"Inhibit, voltage-gated sodium channel","event_type":"KeyEvent"},{"event_id":1355,"event":"Activated, membrane depolarization","event_type":"KeyEvent"},{"event_id":1362,"event":"Increased, hippocampal hyperdepolarization","event_type":"KeyEvent"},{"event_id":1344,"event":"Increased, seizure","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1363,"event":"Increased, epilepsy","event_type":"AdverseOutcome"}],"relationships":[{"relation":1390,"upstream_event_id":1349,"upstream_event":"Activated, presynaptic neuron 1","downstream_event_id":1350,"downstream_event":"Increased, glutamate"},{"relation":1391,"upstream_event_id":1350,"upstream_event":"Increased, glutamate","downstream_event_id":1351,"downstream_event":"Activated, NMDA receptor"},{"relation":1392,"upstream_event_id":1351,"upstream_event":"Activated, NMDA receptor","downstream_event_id":1321,"downstream_event":"Increased, intracellular sodium (Na+)"},{"relation":1393,"upstream_event_id":1321,"upstream_event":"Increased, intracellular sodium (Na+)","downstream_event_id":1352,"downstream_event":"Activated, voltage-gated sodium channel"},{"relation":1394,"upstream_event_id":1352,"upstream_event":"Activated, voltage-gated sodium channel","downstream_event_id":1355,"downstream_event":"Activated, membrane depolarization"},{"relation":1395,"upstream_event_id":1355,"upstream_event":"Activated, membrane depolarization","downstream_event_id":1362,"downstream_event":"Increased, hippocampal hyperdepolarization"},{"relation":1396,"upstream_event_id":1362,"upstream_event":"Increased, hippocampal hyperdepolarization","downstream_event_id":1344,"downstream_event":"Increased, seizure"},{"relation":1397,"upstream_event_id":1344,"upstream_event":"Increased, seizure","downstream_event_id":1363,"downstream_event":"Increased, epilepsy"},{"relation":1398,"upstream_event_id":1354,"upstream_event":"Treat, carbamazepine","downstream_event_id":1353,"downstream_event":"Inhibit, voltage-gated sodium channel"}]}