{"id":228,"title":"NSAID induced PTGS2 inactivation to gastric ulcer","short_name":"NSAID induced PTGS2 inactivation to gastric ulcer","created_at":"2017-06-02T10:50:59.000-04:00","updated_at":"2023-09-25T16:26:56.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":298,"stressor_name":"NSAID (Nonsteroidal anti-inflammatory drug) inhibits PTGS2"}],"aop_mies":[{"event_id":1408,"event":"Reduced, PTGS2 function","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1409,"event":"Decreased, angiogenesis","event_type":"KeyEvent"},{"event_id":1410,"event":"Increased, leukocyte adherence","event_type":"KeyEvent"},{"event_id":1411,"event":"Increased, leukocyte activation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1385,"event":"Activated, gastric ulcer formation","event_type":"AdverseOutcome"}],"relationships":[{"relation":1379,"upstream_event_id":1408,"upstream_event":"Reduced, PTGS2 function","downstream_event_id":1409,"downstream_event":"Decreased, angiogenesis"},{"relation":1380,"upstream_event_id":1409,"upstream_event":"Decreased, angiogenesis","downstream_event_id":1385,"downstream_event":"Activated, gastric ulcer formation"},{"relation":1381,"upstream_event_id":1408,"upstream_event":"Reduced, PTGS2 function","downstream_event_id":1410,"downstream_event":"Increased, leukocyte adherence"},{"relation":1382,"upstream_event_id":1410,"upstream_event":"Increased, leukocyte adherence","downstream_event_id":1411,"downstream_event":"Increased, leukocyte activation"},{"relation":1383,"upstream_event_id":1411,"upstream_event":"Increased, leukocyte activation","downstream_event_id":1385,"downstream_event":"Activated, gastric ulcer formation"}]}