<?xml version="1.0" encoding="UTF-8"?>
<data xmlns="http://www.aopkb.org/aop-xml">
  <stressor id="889ad954-8666-4dcd-9d92-d2d4664acc3f">
    <name>NSAID (Nonsteroidal anti-inflammatory drug) inhibits PTGS1</name>
    <description></description>
    <exposure-characterization></exposure-characterization>
    <creation-timestamp>2017-06-02T10:24:27</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:24:27</last-modification-timestamp>
  </stressor>
  <key-event id="2d684ad5-3be3-4eca-befb-3921e34894cd">
    <title>Reduced, PTGS1 function</title>
    <short-name>Reduced, PTGS1 function</short-name>
    <biological-organization-level>Molecular</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:25:38</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:25:38</last-modification-timestamp>
  </key-event>
  <key-event id="9706247b-be42-4952-83a7-7e2c98698368">
    <title>Activated, gastric ulcer formation</title>
    <short-name>Activated, gastric ulcer formation</short-name>
    <biological-organization-level>Organ</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-04-17T10:47:40</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:26:25</last-modification-timestamp>
  </key-event>
  <key-event id="6424668d-4c16-4674-9551-a460a1f785f3">
    <title>Reduced, platelet aggregation</title>
    <short-name>Reduced, platelet aggregation</short-name>
    <biological-organization-level>Tissue</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:40:24</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:40:24</last-modification-timestamp>
  </key-event>
  <key-event id="d247dabb-2af5-411a-bb03-36423d03f84f">
    <title>Decreased, mucosal blood flow</title>
    <short-name>Decreased, mucosal blood flow</short-name>
    <biological-organization-level>Tissue</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:41:27</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:41:27</last-modification-timestamp>
  </key-event>
  <key-event id="178f5d6e-5cd9-4200-90c3-1c216c0caa07">
    <title>Reduced, mucosal defense</title>
    <short-name>Reduced, mucosal defense</short-name>
    <biological-organization-level>Tissue</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:41:59</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:41:59</last-modification-timestamp>
  </key-event>
  <key-event id="e6b928d9-3c40-48b5-ae95-7c4671e0e438">
    <title>Decreased, mucous</title>
    <short-name>Decreased, mucous</short-name>
    <biological-organization-level>Tissue</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:42:35</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:42:35</last-modification-timestamp>
  </key-event>
  <key-event id="13464d29-7537-4a73-930d-3e5b8b39b24c">
    <title>Decreased, bicarbonate</title>
    <short-name>Decreased, bicarbonate</short-name>
    <biological-organization-level>Tissue</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:43:16</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:43:16</last-modification-timestamp>
  </key-event>
  <key-event-relationship id="050cbceb-ee5c-4db1-b855-5f6214373d31">
    <title>
      <upstream-id>2d684ad5-3be3-4eca-befb-3921e34894cd</upstream-id>
      <downstream-id>6424668d-4c16-4674-9551-a460a1f785f3</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references>#&lt;Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42d4be6cd8&gt;</references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:44:05</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:44:05</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="431ae6d7-f4d3-488c-ac74-054070604c2d">
    <title>
      <upstream-id>6424668d-4c16-4674-9551-a460a1f785f3</upstream-id>
      <downstream-id>9706247b-be42-4952-83a7-7e2c98698368</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references>#&lt;Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43052475c0&gt;</references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:44:22</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:44:22</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="ee6204b5-e1f4-4626-8610-355d5db7cb94">
    <title>
      <upstream-id>2d684ad5-3be3-4eca-befb-3921e34894cd</upstream-id>
      <downstream-id>d247dabb-2af5-411a-bb03-36423d03f84f</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references>#&lt;Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43018934f0&gt;</references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:44:37</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:44:37</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="e19a1ded-e5e9-46cf-b5e5-f512f578ffda">
    <title>
      <upstream-id>d247dabb-2af5-411a-bb03-36423d03f84f</upstream-id>
      <downstream-id>178f5d6e-5cd9-4200-90c3-1c216c0caa07</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references>#&lt;Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4300c3fa78&gt;</references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:44:49</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:44:49</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="15b519b9-c218-4bfe-87cf-c3d307cda8c2">
    <title>
      <upstream-id>178f5d6e-5cd9-4200-90c3-1c216c0caa07</upstream-id>
      <downstream-id>9706247b-be42-4952-83a7-7e2c98698368</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references>#&lt;Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43022bbbd0&gt;</references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:45:04</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:45:04</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="ae96d202-9ed1-436a-a31d-7d1fdf702e83">
    <title>
      <upstream-id>2d684ad5-3be3-4eca-befb-3921e34894cd</upstream-id>
      <downstream-id>e6b928d9-3c40-48b5-ae95-7c4671e0e438</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references>#&lt;Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43011393a8&gt;</references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:45:33</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:45:33</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="78c7028c-2f18-4745-8d5c-5e86dc22dbbd">
    <title>
      <upstream-id>e6b928d9-3c40-48b5-ae95-7c4671e0e438</upstream-id>
      <downstream-id>178f5d6e-5cd9-4200-90c3-1c216c0caa07</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references>#&lt;Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4302216838&gt;</references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:45:58</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:45:58</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="26571462-b570-419b-bcd1-60e4ff531595">
    <title>
      <upstream-id>2d684ad5-3be3-4eca-befb-3921e34894cd</upstream-id>
      <downstream-id>13464d29-7537-4a73-930d-3e5b8b39b24c</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references>#&lt;Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43024e7800&gt;</references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:46:17</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:46:17</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="95a5f369-f5c4-447c-9466-34de51ed6ef4">
    <title>
      <upstream-id>13464d29-7537-4a73-930d-3e5b8b39b24c</upstream-id>
      <downstream-id>178f5d6e-5cd9-4200-90c3-1c216c0caa07</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references>#&lt;Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4302456738&gt;</references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:46:30</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:46:30</last-modification-timestamp>
  </key-event-relationship>
  <aop id="57f17f12-ef55-4720-b9c1-75fe3eb2c102">
    <title>NSAID induced PTGS1 inactivation to gastric ulcer</title>
    <short-name>NSAID induced PTGS1 inactivation to gastric ulcer</short-name>
    <point-of-contact>Allie Always</point-of-contact>
    <authors></authors>
    <coaches>
    </coaches>
    <external_links>
    </external_links>
    <status>
      <wiki-license>Open for adoption</wiki-license>
    </status>
    <oecd-project></oecd-project>
    <handbook-version>1.0</handbook-version>
    <abstract></abstract>
    <molecular-initiating-event key-event-id="2d684ad5-3be3-4eca-befb-3921e34894cd">
      <evidence-supporting-chemical-initiation></evidence-supporting-chemical-initiation>
    </molecular-initiating-event>
    <key-events>
      <key-event key-event-id="6424668d-4c16-4674-9551-a460a1f785f3"/>
      <key-event key-event-id="d247dabb-2af5-411a-bb03-36423d03f84f"/>
      <key-event key-event-id="178f5d6e-5cd9-4200-90c3-1c216c0caa07"/>
      <key-event key-event-id="e6b928d9-3c40-48b5-ae95-7c4671e0e438"/>
      <key-event key-event-id="13464d29-7537-4a73-930d-3e5b8b39b24c"/>
    </key-events>
    <adverse-outcome key-event-id="9706247b-be42-4952-83a7-7e2c98698368">
      <examples></examples>
    </adverse-outcome>
    <key-event-relationships>
      <relationship id="050cbceb-ee5c-4db1-b855-5f6214373d31">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="431ae6d7-f4d3-488c-ac74-054070604c2d">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="ee6204b5-e1f4-4626-8610-355d5db7cb94">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="e19a1ded-e5e9-46cf-b5e5-f512f578ffda">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="15b519b9-c218-4bfe-87cf-c3d307cda8c2">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="ae96d202-9ed1-436a-a31d-7d1fdf702e83">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="78c7028c-2f18-4745-8d5c-5e86dc22dbbd">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="26571462-b570-419b-bcd1-60e4ff531595">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="95a5f369-f5c4-447c-9466-34de51ed6ef4">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
    </key-event-relationships>
    <applicability>
    </applicability>
    <overall-assessment>
      <description></description>
      <applicability></applicability>
      <key-event-essentiality-summary></key-event-essentiality-summary>
      <weight-of-evidence-summary></weight-of-evidence-summary>
      <known-modulating-factors/>
      <quantitative-considerations></quantitative-considerations>
    </overall-assessment>
    <potential-applications></potential-applications>
    <aop-stressors>
      <aop-stressor stressor-id="889ad954-8666-4dcd-9d92-d2d4664acc3f">
        <evidence>Not Specified</evidence>
      </aop-stressor>
    </aop-stressors>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:20:27</creation-timestamp>
    <last-modification-timestamp>2023-09-25T16:26:56</last-modification-timestamp>
  </aop>
  <vendor-specific id="a8dd8abf-a6a8-4c07-9aab-c461e12c90de" name="AopWiki" version="2026-04-03 18:55:29 +0000">
    <stressor-reference id="889ad954-8666-4dcd-9d92-d2d4664acc3f" aop-wiki-id="297"/>
    <key-event-reference id="2d684ad5-3be3-4eca-befb-3921e34894cd" aop-wiki-id="1402"/>
    <key-event-reference id="9706247b-be42-4952-83a7-7e2c98698368" aop-wiki-id="1385"/>
    <key-event-reference id="6424668d-4c16-4674-9551-a460a1f785f3" aop-wiki-id="1403"/>
    <key-event-reference id="d247dabb-2af5-411a-bb03-36423d03f84f" aop-wiki-id="1404"/>
    <key-event-reference id="178f5d6e-5cd9-4200-90c3-1c216c0caa07" aop-wiki-id="1405"/>
    <key-event-reference id="e6b928d9-3c40-48b5-ae95-7c4671e0e438" aop-wiki-id="1406"/>
    <key-event-reference id="13464d29-7537-4a73-930d-3e5b8b39b24c" aop-wiki-id="1407"/>
    <key-event-relationship-reference id="050cbceb-ee5c-4db1-b855-5f6214373d31" aop-wiki-id="1532"/>
    <key-event-relationship-reference id="431ae6d7-f4d3-488c-ac74-054070604c2d" aop-wiki-id="1533"/>
    <key-event-relationship-reference id="ee6204b5-e1f4-4626-8610-355d5db7cb94" aop-wiki-id="1534"/>
    <key-event-relationship-reference id="e19a1ded-e5e9-46cf-b5e5-f512f578ffda" aop-wiki-id="1535"/>
    <key-event-relationship-reference id="15b519b9-c218-4bfe-87cf-c3d307cda8c2" aop-wiki-id="1536"/>
    <key-event-relationship-reference id="ae96d202-9ed1-436a-a31d-7d1fdf702e83" aop-wiki-id="1537"/>
    <key-event-relationship-reference id="78c7028c-2f18-4745-8d5c-5e86dc22dbbd" aop-wiki-id="1538"/>
    <key-event-relationship-reference id="26571462-b570-419b-bcd1-60e4ff531595" aop-wiki-id="1539"/>
    <key-event-relationship-reference id="95a5f369-f5c4-447c-9466-34de51ed6ef4" aop-wiki-id="1540"/>
    <aop-reference id="57f17f12-ef55-4720-b9c1-75fe3eb2c102" aop-wiki-id="227"/>
  </vendor-specific>
</data>
