{"id":227,"title":"NSAID induced PTGS1 inactivation to gastric ulcer","short_name":"NSAID induced PTGS1 inactivation to gastric ulcer","created_at":"2017-06-02T10:20:27.000-04:00","updated_at":"2023-09-25T16:26:56.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":297,"stressor_name":"NSAID (Nonsteroidal anti-inflammatory drug) inhibits PTGS1"}],"aop_mies":[{"event_id":1402,"event":"Reduced, PTGS1 function","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1403,"event":"Reduced, platelet aggregation","event_type":"KeyEvent"},{"event_id":1404,"event":"Decreased, mucosal blood flow","event_type":"KeyEvent"},{"event_id":1405,"event":"Reduced, mucosal defense","event_type":"KeyEvent"},{"event_id":1406,"event":"Decreased, mucous","event_type":"KeyEvent"},{"event_id":1407,"event":"Decreased, bicarbonate","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1385,"event":"Activated, gastric ulcer formation","event_type":"AdverseOutcome"}],"relationships":[{"relation":1370,"upstream_event_id":1402,"upstream_event":"Reduced, PTGS1 function","downstream_event_id":1403,"downstream_event":"Reduced, platelet aggregation"},{"relation":1371,"upstream_event_id":1403,"upstream_event":"Reduced, platelet aggregation","downstream_event_id":1385,"downstream_event":"Activated, gastric ulcer formation"},{"relation":1372,"upstream_event_id":1402,"upstream_event":"Reduced, PTGS1 function","downstream_event_id":1404,"downstream_event":"Decreased, mucosal blood flow"},{"relation":1373,"upstream_event_id":1404,"upstream_event":"Decreased, mucosal blood flow","downstream_event_id":1405,"downstream_event":"Reduced, mucosal defense"},{"relation":1374,"upstream_event_id":1405,"upstream_event":"Reduced, mucosal defense","downstream_event_id":1385,"downstream_event":"Activated, gastric ulcer formation"},{"relation":1375,"upstream_event_id":1402,"upstream_event":"Reduced, PTGS1 function","downstream_event_id":1406,"downstream_event":"Decreased, mucous"},{"relation":1376,"upstream_event_id":1406,"upstream_event":"Decreased, mucous","downstream_event_id":1405,"downstream_event":"Reduced, mucosal defense"},{"relation":1377,"upstream_event_id":1402,"upstream_event":"Reduced, PTGS1 function","downstream_event_id":1407,"downstream_event":"Decreased, bicarbonate"},{"relation":1378,"upstream_event_id":1407,"upstream_event":"Decreased, bicarbonate","downstream_event_id":1405,"downstream_event":"Reduced, mucosal defense"}]}