{"id":226,"title":"SSRI (Selective serotonin reuptake inhibitor) to hypertension","short_name":"SSRI to hypertension","created_at":"2017-05-30T20:30:22.000-04:00","updated_at":"2023-09-25T16:26:56.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":270,"stressor_name":"SSRI (Selective serotonin reuptake inhibitor)"}],"aop_mies":[{"event_id":1317,"event":"Decreased, serotonin transporter activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1323,"event":"Decreased, intracellular serotonin","event_type":"KeyEvent"},{"event_id":1324,"event":"Decreased, packaged serotonin","event_type":"KeyEvent"},{"event_id":1325,"event":"Decreased, synaptic release","event_type":"KeyEvent"},{"event_id":1320,"event":"Increased, extracellular serotonin","event_type":"KeyEvent"},{"event_id":1347,"event":"Decreased, extracellular serotonin","event_type":"KeyEvent"},{"event_id":1336,"event":"Activation, 5-HT2A (Serotonin 2A)","event_type":"KeyEvent"},{"event_id":1337,"event":"Activate, PLC (Phospholipase C)","event_type":"KeyEvent"},{"event_id":1338,"event":"Increase, inositol triphosphate","event_type":"KeyEvent"},{"event_id":1339,"event":"Increase, intracellular calcium","event_type":"KeyEvent"},{"event_id":1340,"event":"Activate, calmodulin","event_type":"KeyEvent"},{"event_id":1341,"event":"Increase, myosin light chain phosphorylation","event_type":"KeyEvent"},{"event_id":1342,"event":"Increase, vascular smooth muscle contraction","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1343,"event":"Increase, hypertension","event_type":"AdverseOutcome"}],"relationships":[{"relation":1367,"upstream_event_id":1317,"upstream_event":"Decreased, serotonin transporter activity","downstream_event_id":1323,"downstream_event":"Decreased, intracellular serotonin"},{"relation":1329,"upstream_event_id":1323,"upstream_event":"Decreased, intracellular serotonin","downstream_event_id":1324,"downstream_event":"Decreased, packaged serotonin"},{"relation":1330,"upstream_event_id":1324,"upstream_event":"Decreased, packaged serotonin","downstream_event_id":1325,"downstream_event":"Decreased, synaptic release"},{"relation":1331,"upstream_event_id":1325,"upstream_event":"Decreased, synaptic release","downstream_event_id":1347,"downstream_event":"Decreased, extracellular serotonin"},{"relation":1368,"upstream_event_id":1317,"upstream_event":"Decreased, serotonin transporter activity","downstream_event_id":1320,"downstream_event":"Increased, extracellular serotonin"},{"relation":1369,"upstream_event_id":1320,"upstream_event":"Increased, extracellular serotonin","downstream_event_id":1336,"downstream_event":"Activation, 5-HT2A (Serotonin 2A)"},{"relation":1334,"upstream_event_id":1336,"upstream_event":"Activation, 5-HT2A (Serotonin 2A)","downstream_event_id":1337,"downstream_event":"Activate, PLC (Phospholipase C)"},{"relation":1335,"upstream_event_id":1337,"upstream_event":"Activate, PLC (Phospholipase C)","downstream_event_id":1338,"downstream_event":"Increase, inositol triphosphate"},{"relation":1336,"upstream_event_id":1338,"upstream_event":"Increase, inositol triphosphate","downstream_event_id":1339,"downstream_event":"Increase, intracellular calcium"},{"relation":1337,"upstream_event_id":1339,"upstream_event":"Increase, intracellular calcium","downstream_event_id":1340,"downstream_event":"Activate, calmodulin"},{"relation":1338,"upstream_event_id":1340,"upstream_event":"Activate, calmodulin","downstream_event_id":1341,"downstream_event":"Increase, myosin light chain phosphorylation"},{"relation":1339,"upstream_event_id":1341,"upstream_event":"Increase, myosin light chain phosphorylation","downstream_event_id":1342,"downstream_event":"Increase, vascular smooth muscle contraction"},{"relation":1340,"upstream_event_id":1342,"upstream_event":"Increase, vascular smooth muscle contraction","downstream_event_id":1343,"downstream_event":"Increase, hypertension"}]}