{"id":225,"title":"Serotonin transporter activation to agitation","short_name":"Serotonin transporter activation to agitation","created_at":"2017-05-30T20:08:34.000-04:00","updated_at":"2023-09-25T16:26:56.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":295,"stressor_name":"serotonin transporter activation"}],"aop_mies":[],"aop_kes":[{"event_id":1397,"event":"Increased, serotonin transporter activity","event_type":"KeyEvent"},{"event_id":1398,"event":"Increased, intracellular serotonin","event_type":"KeyEvent"},{"event_id":1399,"event":"Increased, packaged serotonin","event_type":"KeyEvent"},{"event_id":1320,"event":"Increased, extracellular serotonin","event_type":"KeyEvent"},{"event_id":1347,"event":"Decreased, extracellular serotonin","event_type":"KeyEvent"},{"event_id":1328,"event":"Inactivated, 5-HTR (serotonin receptors)","event_type":"KeyEvent"},{"event_id":1329,"event":"Reduce expression, BDNF (Brain-derived neurotrophic factor)","event_type":"KeyEvent"},{"event_id":1330,"event":"Decreased, neuroplasticity","event_type":"KeyEvent"},{"event_id":1400,"event":"Increased, synaptic release","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1345,"event":"Increased, agitation","event_type":"AdverseOutcome"}],"relationships":[{"relation":1324,"upstream_event_id":1347,"upstream_event":"Decreased, extracellular serotonin","downstream_event_id":1328,"downstream_event":"Inactivated, 5-HTR (serotonin receptors)"},{"relation":1325,"upstream_event_id":1328,"upstream_event":"Inactivated, 5-HTR (serotonin receptors)","downstream_event_id":1329,"downstream_event":"Reduce expression, BDNF (Brain-derived neurotrophic factor)"},{"relation":1326,"upstream_event_id":1329,"upstream_event":"Reduce expression, BDNF (Brain-derived neurotrophic factor)","downstream_event_id":1330,"downstream_event":"Decreased, neuroplasticity"},{"relation":1327,"upstream_event_id":1330,"upstream_event":"Decreased, neuroplasticity","downstream_event_id":1345,"downstream_event":"Increased, agitation"},{"relation":1362,"upstream_event_id":1397,"upstream_event":"Increased, serotonin transporter activity","downstream_event_id":1398,"downstream_event":"Increased, intracellular serotonin"},{"relation":1363,"upstream_event_id":1398,"upstream_event":"Increased, intracellular serotonin","downstream_event_id":1399,"downstream_event":"Increased, packaged serotonin"},{"relation":1364,"upstream_event_id":1399,"upstream_event":"Increased, packaged serotonin","downstream_event_id":1400,"downstream_event":"Increased, synaptic release"},{"relation":1365,"upstream_event_id":1400,"upstream_event":"Increased, synaptic release","downstream_event_id":1320,"downstream_event":"Increased, extracellular serotonin"},{"relation":1366,"upstream_event_id":1397,"upstream_event":"Increased, serotonin transporter activity","downstream_event_id":1347,"downstream_event":"Decreased, extracellular serotonin"}]}