Increased, extracellular serotonin

serotonin transporter activation

2017-05-30T15:46:36

2017-06-01T11:53:09

Molecular

AOPWiki 2017-04-13T14:20:14

2017-05-31T16:48:15

Decreased, extracellular serotonin

Molecular

AOPWiki 2017-04-14T14:38:23

2017-05-31T16:46:08

Increased, seizure

Individual

AOPWiki 2017-04-13T15:35:33

2017-06-01T11:55:50

Increased, serotonin transporter activity

Cellular

AOPWiki 2017-06-01T14:51:06

2017-06-01T14:51:06

Increased, intracellular serotonin

Cellular

AOPWiki 2017-06-01T14:51:55

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Increased, packaged serotonin

Cellular

AOPWiki 2017-06-01T14:52:30

2017-06-01T14:52:30

Increased, synaptic release

Cellular

AOPWiki 2017-06-01T14:53:16

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Decreased, 5-HT3

Tissue

AOPWiki 2017-06-01T14:54:19

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#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb89f3885e0> AOPWiki 2017-06-01T14:55:32

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#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a0c09970> AOPWiki 2017-06-01T14:55:50

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<upstream-id>1eb4d1a6-32ac-461a-97b3-2d94fbaad67b</upstream-id> <downstream-id>eae7d02c-06aa-45c7-83de-ad68424a36bb</downstream-id>

#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a0d454b0> AOPWiki 2017-06-01T14:56:06

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<upstream-id>eae7d02c-06aa-45c7-83de-ad68424a36bb</upstream-id> <downstream-id>bc5e17ed-d0a9-44d6-b1fe-9eb9ef26a4e1</downstream-id>

#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a0e27540> AOPWiki 2017-06-01T14:56:34

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<upstream-id>58d871d5-5950-4037-905f-8a1952ea1204</upstream-id> <downstream-id>8957f29b-7610-4b92-8448-b23e35f00a7d</downstream-id>

#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a0e66e70> AOPWiki 2017-06-01T14:56:55

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<upstream-id>bc5e17ed-d0a9-44d6-b1fe-9eb9ef26a4e1</upstream-id> <downstream-id>e46dd93e-0fff-4bd3-9bb7-3edda0ff6dc0</downstream-id>

#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a0f8bfa8> AOPWiki 2017-06-01T14:57:34

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<upstream-id>e46dd93e-0fff-4bd3-9bb7-3edda0ff6dc0</upstream-id> <downstream-id>8c603f9d-37bb-422b-b0c3-0e872988ad7f</downstream-id>

#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a11c5e68> AOPWiki 2017-06-01T14:58:10

2017-06-01T14:58:10

Serotonin transporter activation to seizure

Cataia Ives

Open for adoption

1.0

<p>Larry: The serotonin transporter may be repressed by SSRI, thus extracellular serotonin is increased and seizure is reduced. However, I did not add this "SSRI inhibits serotonin transporter" relationship into the AOP since SSRI inhibition does not contribute directly to the AOP (It modified the MIE "the activation of serotonin transporter"), but it certainly could be a modifier to prevent the adverse outcome.</p>

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AOPWiki 2017-05-30T15:45:53

2023-09-25T16:26:56