{"id":222,"title":"Mental stress to agitation","short_name":"Mental stress to agitation","created_at":"2017-05-30T15:12:23.000-04:00","updated_at":"2023-09-25T16:26:56.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":272,"stressor_name":"Increase cortisone levels (induced by stress)"}],"aop_mies":[{"event_id":1396,"event":"Increased, glucocorticoid receptor activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1335,"event":"Reduced, BDNF (Brain-derived neurotrophic factor)","event_type":"KeyEvent"},{"event_id":1329,"event":"Reduce expression, BDNF (Brain-derived neurotrophic factor)","event_type":"KeyEvent"},{"event_id":1328,"event":"Inactivated, 5-HTR (serotonin receptors)","event_type":"KeyEvent"},{"event_id":1330,"event":"Decreased, neuroplasticity","event_type":"KeyEvent"},{"event_id":1347,"event":"Decreased, extracellular serotonin","event_type":"KeyEvent"},{"event_id":1317,"event":"Decreased, serotonin transporter activity","event_type":"KeyEvent"},{"event_id":1320,"event":"Increased, extracellular serotonin","event_type":"KeyEvent"},{"event_id":1325,"event":"Decreased, synaptic release","event_type":"KeyEvent"},{"event_id":1324,"event":"Decreased, packaged serotonin","event_type":"KeyEvent"},{"event_id":1323,"event":"Decreased, intracellular serotonin","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1345,"event":"Increased, agitation","event_type":"AdverseOutcome"}],"relationships":[{"relation":1345,"upstream_event_id":1396,"upstream_event":"Increased, glucocorticoid receptor activity","downstream_event_id":1335,"downstream_event":"Reduced, BDNF (Brain-derived neurotrophic factor)"},{"relation":1292,"upstream_event_id":1329,"upstream_event":"Reduce expression, BDNF (Brain-derived neurotrophic factor)","downstream_event_id":1330,"downstream_event":"Decreased, neuroplasticity"},{"relation":1294,"upstream_event_id":1330,"upstream_event":"Decreased, neuroplasticity","downstream_event_id":1345,"downstream_event":"Increased, agitation"},{"relation":1293,"upstream_event_id":1328,"upstream_event":"Inactivated, 5-HTR (serotonin receptors)","downstream_event_id":1335,"downstream_event":"Reduced, BDNF (Brain-derived neurotrophic factor)"},{"relation":1295,"upstream_event_id":1347,"upstream_event":"Decreased, extracellular serotonin","downstream_event_id":1328,"downstream_event":"Inactivated, 5-HTR (serotonin receptors)"},{"relation":1296,"upstream_event_id":1317,"upstream_event":"Decreased, serotonin transporter activity","downstream_event_id":1320,"downstream_event":"Increased, extracellular serotonin"},{"relation":1297,"upstream_event_id":1317,"upstream_event":"Decreased, serotonin transporter activity","downstream_event_id":1323,"downstream_event":"Decreased, intracellular serotonin"},{"relation":1298,"upstream_event_id":1323,"upstream_event":"Decreased, intracellular serotonin","downstream_event_id":1324,"downstream_event":"Decreased, packaged serotonin"},{"relation":1299,"upstream_event_id":1324,"upstream_event":"Decreased, packaged serotonin","downstream_event_id":1325,"downstream_event":"Decreased, synaptic release"},{"relation":1300,"upstream_event_id":1325,"upstream_event":"Decreased, synaptic release","downstream_event_id":1347,"downstream_event":"Decreased, extracellular serotonin"}]}