{"id":220,"title":"Cyp2E1 Activation Leading to Liver Cancer","short_name":"Cyp2E1 Activation Leading to Liver Cancer","created_at":"2017-05-30T13:25:04.000-04:00","updated_at":"2023-09-25T16:26:56.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":296,"stressor_name":"\u003e85 known Cyp2E1 substrates"}],"aop_mies":[{"event_id":1391,"event":"Activation of Cyp2E1","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1392,"event":"Oxidative Stress ","event_type":"KeyEvent"},{"event_id":1393,"event":"Hepatocytotoxicity","event_type":"KeyEvent"},{"event_id":1394,"event":"Induction, persistent proliferation/sustained proliferation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1395,"event":"Liver Cancer","event_type":"AdverseOutcome"}],"relationships":[{"relation":1283,"upstream_event_id":1391,"upstream_event":"Activation of Cyp2E1","downstream_event_id":1392,"downstream_event":"Oxidative Stress "},{"relation":1284,"upstream_event_id":1392,"upstream_event":"Oxidative Stress ","downstream_event_id":1393,"downstream_event":"Hepatocytotoxicity"},{"relation":1285,"upstream_event_id":1393,"upstream_event":"Hepatocytotoxicity","downstream_event_id":1394,"downstream_event":"Induction, persistent proliferation/sustained proliferation"},{"relation":1286,"upstream_event_id":1391,"upstream_event":"Activation of Cyp2E1","downstream_event_id":1393,"downstream_event":"Hepatocytotoxicity"},{"relation":1287,"upstream_event_id":1392,"upstream_event":"Oxidative Stress ","downstream_event_id":1395,"downstream_event":"Liver Cancer"},{"relation":1288,"upstream_event_id":1393,"upstream_event":"Hepatocytotoxicity","downstream_event_id":1395,"downstream_event":"Liver Cancer"},{"relation":1289,"upstream_event_id":1394,"upstream_event":"Induction, persistent proliferation/sustained proliferation","downstream_event_id":1395,"downstream_event":"Liver Cancer"}]}