{"id":215,"title":"Molecular events lead to epilepsy","short_name":"Molecular events lead to epilepsy","created_at":"2017-04-14T14:58:30.000-04:00","updated_at":"2023-09-25T16:26:56.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[],"aop_kes":[{"event_id":1349,"event":"Activated, presynaptic neuron 1","event_type":"KeyEvent"},{"event_id":1350,"event":"Increased, glutamate","event_type":"KeyEvent"},{"event_id":1351,"event":"Activated, NMDA receptor","event_type":"KeyEvent"},{"event_id":1321,"event":"Increased, intracellular sodium (Na+)","event_type":"KeyEvent"},{"event_id":1352,"event":"Activated, voltage-gated sodium channel","event_type":"KeyEvent"},{"event_id":1353,"event":"Inhibit, voltage-gated sodium channel","event_type":"KeyEvent"},{"event_id":1354,"event":"Treat, carbamazepine","event_type":"KeyEvent"},{"event_id":1355,"event":"Activated, membrane depolarization","event_type":"KeyEvent"},{"event_id":1356,"event":"Inactive, membrane depolarization","event_type":"KeyEvent"},{"event_id":1357,"event":"Increased, RDX dose","event_type":"KeyEvent"},{"event_id":1358,"event":"Repress, GABA-A receptor","event_type":"KeyEvent"},{"event_id":1359,"event":"Activate, GABA-A receptor","event_type":"KeyEvent"},{"event_id":1360,"event":"Activate, presynaptic neuron 2","event_type":"KeyEvent"},{"event_id":1361,"event":"Increase, GABA","event_type":"KeyEvent"},{"event_id":1322,"event":"Increased, intracellular chloride (Cl-)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1348,"event":"Increase, seizure","event_type":"AdverseOutcome"},{"event_id":1362,"event":"Increased, hippocampal hyperdepolarization","event_type":"AdverseOutcome"},{"event_id":1363,"event":"Increased, epilepsy","event_type":"AdverseOutcome"}],"relationships":[{"relation":1203,"upstream_event_id":1349,"upstream_event":"Activated, presynaptic neuron 1","downstream_event_id":1350,"downstream_event":"Increased, glutamate"},{"relation":1204,"upstream_event_id":1350,"upstream_event":"Increased, glutamate","downstream_event_id":1351,"downstream_event":"Activated, NMDA receptor"},{"relation":1205,"upstream_event_id":1351,"upstream_event":"Activated, NMDA receptor","downstream_event_id":1321,"downstream_event":"Increased, intracellular sodium (Na+)"},{"relation":1206,"upstream_event_id":1321,"upstream_event":"Increased, intracellular sodium (Na+)","downstream_event_id":1352,"downstream_event":"Activated, voltage-gated sodium channel"},{"relation":1207,"upstream_event_id":1354,"upstream_event":"Treat, carbamazepine","downstream_event_id":1353,"downstream_event":"Inhibit, voltage-gated sodium channel"},{"relation":1208,"upstream_event_id":1352,"upstream_event":"Activated, voltage-gated sodium channel","downstream_event_id":1355,"downstream_event":"Activated, membrane depolarization"},{"relation":1209,"upstream_event_id":1355,"upstream_event":"Activated, membrane depolarization","downstream_event_id":1362,"downstream_event":"Increased, hippocampal hyperdepolarization"},{"relation":1210,"upstream_event_id":1362,"upstream_event":"Increased, hippocampal hyperdepolarization","downstream_event_id":1348,"downstream_event":"Increase, seizure"},{"relation":1211,"upstream_event_id":1348,"upstream_event":"Increase, seizure","downstream_event_id":1363,"downstream_event":"Increased, epilepsy"},{"relation":1212,"upstream_event_id":1360,"upstream_event":"Activate, presynaptic neuron 2","downstream_event_id":1361,"downstream_event":"Increase, GABA"},{"relation":1213,"upstream_event_id":1361,"upstream_event":"Increase, GABA","downstream_event_id":1359,"downstream_event":"Activate, GABA-A receptor"},{"relation":1214,"upstream_event_id":1357,"upstream_event":"Increased, RDX dose","downstream_event_id":1359,"downstream_event":"Activate, GABA-A receptor"},{"relation":1215,"upstream_event_id":1359,"upstream_event":"Activate, GABA-A receptor","downstream_event_id":1322,"downstream_event":"Increased, intracellular chloride (Cl-)"},{"relation":1216,"upstream_event_id":1322,"upstream_event":"Increased, intracellular chloride (Cl-)","downstream_event_id":1356,"downstream_event":"Inactive, membrane depolarization"}]}