{"id":213,"title":"Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)","short_name":"Inhibition fatty acid beta oxidation leading to nonalcoholic steatohepatisis (NASH) ","created_at":"2017-04-12T13:28:27.000-04:00","updated_at":"2023-09-25T16:26:55.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1490,"event":"Inhibition, Fatty Acid Beta Oxidation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1305,"event":"Increase, cytosolic fatty acid","event_type":"KeyEvent"},{"event_id":459,"event":"Increased, Liver Steatosis","event_type":"KeyEvent"},{"event_id":1115,"event":"Increased, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":1491,"event":"Increased, Oncotic Necrosis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1489,"event":"N/A, Steatohepatisis","event_type":"AdverseOutcome"}],"relationships":[{"relation":1575,"upstream_event_id":1490,"upstream_event":"Inhibition, Fatty Acid Beta Oxidation","downstream_event_id":1305,"downstream_event":"Increase, cytosolic fatty acid"},{"relation":1577,"upstream_event_id":1305,"upstream_event":"Increase, cytosolic fatty acid","downstream_event_id":459,"downstream_event":"Increased, Liver Steatosis"},{"relation":1578,"upstream_event_id":459,"upstream_event":"Increased, Liver Steatosis","downstream_event_id":1115,"downstream_event":"Increased, Reactive oxygen species"},{"relation":1579,"upstream_event_id":1115,"upstream_event":"Increased, Reactive oxygen species","downstream_event_id":1491,"downstream_event":"Increased, Oncotic Necrosis"},{"relation":1580,"upstream_event_id":1491,"upstream_event":"Increased, Oncotic Necrosis","downstream_event_id":1489,"downstream_event":"N/A, Steatohepatisis"}]}