{"id":210,"title":"Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building","short_name":"JNK, FOXO and WNT alteration leading to reproductive failure: Multi-OMICS approach","created_at":"2017-02-15T04:35:06.000-05:00","updated_at":"2023-09-25T16:26:55.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":255,"stressor_name":"Graphene oxide nanoparticles"}],"aop_mies":[],"aop_kes":[{"event_id":209,"event":"Peptide Oxidation","event_type":"KeyEvent"},{"event_id":1292,"event":"Activation, JNK","event_type":"KeyEvent"},{"event_id":1293,"event":"Activation, FOXO","event_type":"KeyEvent"},{"event_id":1294,"event":"Inhibition, Wnt pathway","event_type":"KeyEvent"},{"event_id":1295,"event":"Defect of Embryogenesis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1277,"event":"Reproductive failure","event_type":"AdverseOutcome"}],"relationships":[{"relation":1116,"upstream_event_id":209,"upstream_event":"Peptide Oxidation","downstream_event_id":1292,"downstream_event":"Activation, JNK"},{"relation":1117,"upstream_event_id":1292,"upstream_event":"Activation, JNK","downstream_event_id":1293,"downstream_event":"Activation, FOXO"},{"relation":1118,"upstream_event_id":1293,"upstream_event":"Activation, FOXO","downstream_event_id":1294,"downstream_event":"Inhibition, Wnt pathway"},{"relation":1119,"upstream_event_id":1294,"upstream_event":"Inhibition, Wnt pathway","downstream_event_id":1295,"downstream_event":"Defect of Embryogenesis"},{"relation":1120,"upstream_event_id":1295,"upstream_event":"Defect of Embryogenesis","downstream_event_id":1277,"downstream_event":"Reproductive failure"}]}