{"id":206,"title":"Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis","short_name":"PPARγ inactivation leading to lung fibrosis","created_at":"2017-02-15T02:34:56.000-05:00","updated_at":"2023-09-25T16:26:55.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1270,"event":"Inactivation of PPARγ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1271,"event":"Activation of TGF-β signaling","event_type":"KeyEvent"},{"event_id":149,"event":"Increase, Inflammation","event_type":"KeyEvent"},{"event_id":1275,"event":"Collagen Deposition","event_type":"KeyEvent"},{"event_id":1457,"event":"Induction, Epithelial Mesenchymal Transition","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1276,"event":"Lung fibrosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":1090,"upstream_event_id":1270,"upstream_event":"Inactivation of PPARγ","downstream_event_id":1271,"downstream_event":"Activation of TGF-β signaling"},{"relation":1614,"upstream_event_id":149,"upstream_event":"Increase, Inflammation","downstream_event_id":1457,"downstream_event":"Induction, Epithelial Mesenchymal Transition"},{"relation":1096,"upstream_event_id":1275,"upstream_event":"Collagen Deposition","downstream_event_id":1276,"downstream_event":"Lung fibrosis"},{"relation":1700,"upstream_event_id":1271,"upstream_event":"Activation of TGF-β signaling","downstream_event_id":149,"downstream_event":"Increase, Inflammation"},{"relation":1701,"upstream_event_id":1457,"upstream_event":"Induction, Epithelial Mesenchymal Transition","downstream_event_id":1275,"downstream_event":"Collagen Deposition"}]}