{"id":203,"title":"5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline","short_name":"5-HTT leading to population decline","created_at":"2017-01-13T12:23:22.000-05:00","updated_at":"2023-09-25T16:26:55.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":202,"stressor_name":"Fluoxetine"},{"stressor_id":233,"stressor_name":"sertraline"},{"stressor_id":203,"stressor_name":"Fluvoxamine"},{"stressor_id":234,"stressor_name":"norfluoxetine"}],"aop_mies":[{"event_id":619,"event":"Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1142,"event":"Increased, valve movement","event_type":"KeyEvent"},{"event_id":621,"event":"Increase, cilia movement","event_type":"KeyEvent"},{"event_id":1256,"event":"increased mantel display","event_type":"KeyEvent"},{"event_id":1257,"event":"Induced parturition","event_type":"KeyEvent"},{"event_id":626,"event":"Increased, serotonin (5-HT) ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1141,"event":"Decreased, Reproductive Success","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":1022,"upstream_event_id":619,"upstream_event":"Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)","downstream_event_id":1142,"downstream_event":"Increased, valve movement"},{"relation":1023,"upstream_event_id":619,"upstream_event":"Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)","downstream_event_id":621,"downstream_event":"Increase, cilia movement"},{"relation":1024,"upstream_event_id":619,"upstream_event":"Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)","downstream_event_id":1256,"downstream_event":"increased mantel display"},{"relation":1027,"upstream_event_id":1256,"upstream_event":"increased mantel display","downstream_event_id":1257,"downstream_event":"Induced parturition"},{"relation":1028,"upstream_event_id":1257,"upstream_event":"Induced parturition","downstream_event_id":1141,"downstream_event":"Decreased, Reproductive Success"},{"relation":1063,"upstream_event_id":1142,"upstream_event":"Increased, valve movement","downstream_event_id":1257,"downstream_event":"Induced parturition"},{"relation":1064,"upstream_event_id":621,"upstream_event":"Increase, cilia movement","downstream_event_id":1257,"downstream_event":"Induced parturition"},{"relation":1065,"upstream_event_id":626,"upstream_event":"Increased, serotonin (5-HT) ","downstream_event_id":1142,"downstream_event":"Increased, valve movement"},{"relation":1066,"upstream_event_id":626,"upstream_event":"Increased, serotonin (5-HT) ","downstream_event_id":621,"downstream_event":"Increase, cilia movement"},{"relation":1067,"upstream_event_id":626,"upstream_event":"Increased, serotonin (5-HT) ","downstream_event_id":1256,"downstream_event":"increased mantel display"},{"relation":1068,"upstream_event_id":619,"upstream_event":"Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)","downstream_event_id":626,"downstream_event":"Increased, serotonin (5-HT) "},{"relation":3063,"upstream_event_id":1141,"upstream_event":"Decreased, Reproductive Success","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}