{"id":196,"title":"Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation","short_name":"TRPA1 activation leads to pulmonary sensory irritation","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:55.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":235,"stressor_name":"Dibenzo[B,F][1,4]Oxazepine"},{"stressor_id":236,"stressor_name":"2-Chlorobenzalmalononitrile"}],"aop_mies":[{"event_id":1215,"event":"TRPA1 activation, TRPA1 Receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1218,"event":"Opening of calcium channel, Calcium influx","event_type":"KeyEvent"},{"event_id":1220,"event":"Trigeminal nerve activation","event_type":"KeyEvent"},{"event_id":1222,"event":"SP (Substance P) release, Local increase of SP","event_type":"KeyEvent"},{"event_id":1433,"event":"Increased CGRP, neuronal release of CGRP","event_type":"KeyEvent"},{"event_id":1435,"event":"Increased neurokinin A (NKA) by neuronal cells","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1223,"event":"Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea","event_type":"AdverseOutcome"},{"event_id":1434,"event":"Irritation of nasal mucosa inducing sneeze reflex","event_type":"AdverseOutcome"},{"event_id":1226,"event":"Increased Respiratory irritability and Chronic Cough, ","event_type":"AdverseOutcome"}],"relationships":[{"relation":964,"upstream_event_id":1215,"upstream_event":"TRPA1 activation, TRPA1 Receptor","downstream_event_id":1218,"downstream_event":"Opening of calcium channel, Calcium influx"},{"relation":965,"upstream_event_id":1218,"upstream_event":"Opening of calcium channel, Calcium influx","downstream_event_id":1220,"downstream_event":"Trigeminal nerve activation"},{"relation":1432,"upstream_event_id":1220,"upstream_event":"Trigeminal nerve activation","downstream_event_id":1222,"downstream_event":"SP (Substance P) release, Local increase of SP"},{"relation":1435,"upstream_event_id":1220,"upstream_event":"Trigeminal nerve activation","downstream_event_id":1433,"downstream_event":"Increased CGRP, neuronal release of CGRP"},{"relation":1440,"upstream_event_id":1220,"upstream_event":"Trigeminal nerve activation","downstream_event_id":1435,"downstream_event":"Increased neurokinin A (NKA) by neuronal cells"},{"relation":1688,"upstream_event_id":1222,"upstream_event":"SP (Substance P) release, Local increase of SP","downstream_event_id":1226,"downstream_event":"Increased Respiratory irritability and Chronic Cough, "},{"relation":1689,"upstream_event_id":1433,"upstream_event":"Increased CGRP, neuronal release of CGRP","downstream_event_id":1226,"downstream_event":"Increased Respiratory irritability and Chronic Cough, "},{"relation":1690,"upstream_event_id":1435,"upstream_event":"Increased neurokinin A (NKA) by neuronal cells","downstream_event_id":1226,"downstream_event":"Increased Respiratory irritability and Chronic Cough, "},{"relation":1691,"upstream_event_id":1226,"upstream_event":"Increased Respiratory irritability and Chronic Cough, ","downstream_event_id":1223,"downstream_event":"Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea"},{"relation":1692,"upstream_event_id":1220,"upstream_event":"Trigeminal nerve activation","downstream_event_id":1434,"downstream_event":"Irritation of nasal mucosa inducing sneeze reflex"}]}