{"id":194,"title":"Hepatic nuclear receptor activation leading to altered amphibian metamorphosis","short_name":"Hepatic nuclear receptor activation alters metamorphosis","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:54.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1157,"event":"Activation, Hepatic nuclear receptor(s)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1158,"event":"Increased, Hepatic thyroid hormone uptake/transport","event_type":"KeyEvent"},{"event_id":295,"event":"Induction, Upregulation of glucuronyltransferase activity","event_type":"KeyEvent"},{"event_id":961,"event":"Increased, Clearance of thyroxine from serum","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1101,"event":"Altered, Amphibian metamorphosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":898,"upstream_event_id":1157,"upstream_event":"Activation, Hepatic nuclear receptor(s)","downstream_event_id":1158,"downstream_event":"Increased, Hepatic thyroid hormone uptake/transport"},{"relation":899,"upstream_event_id":1157,"upstream_event":"Activation, Hepatic nuclear receptor(s)","downstream_event_id":295,"downstream_event":"Induction, Upregulation of glucuronyltransferase activity"},{"relation":2440,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":1101,"downstream_event":"Altered, Amphibian metamorphosis"},{"relation":2439,"upstream_event_id":1158,"upstream_event":"Increased, Hepatic thyroid hormone uptake/transport","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2819,"upstream_event_id":295,"upstream_event":"Induction, Upregulation of glucuronyltransferase activity","downstream_event_id":961,"downstream_event":"Increased, Clearance of thyroxine from serum"},{"relation":2820,"upstream_event_id":961,"upstream_event":"Increased, Clearance of thyroxine from serum","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2821,"upstream_event_id":1158,"upstream_event":"Increased, Hepatic thyroid hormone uptake/transport","downstream_event_id":961,"downstream_event":"Increased, Clearance of thyroxine from serum"}]}