81-81-2 PJVWKTKQMONHTI-UHFFFAOYNA-N PJVWKTKQMONHTI-UHFFFAOYSA-N Warfarin Coumadin 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)- (.+-.)-Warfarin (.+-.)-Warfarin-alcohol (RS)-Warfarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone 3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin 3-(α-Acetonylbenzyl)-4-hydroxycoumarin 3-(α-Phenyl-β-acetylethyl)-4-hydroxycoumarin 3-(α-Phenyl-β-acetylethyl)-4-hydroxy-coumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one Athrombine-K BENZOPYRAN(2H-1)-2-ONE, 4-HYDROXY-3-(3-OXO-1- PHENYLBUTYL)- Brumolin Coumafen Coumafene Coumaphen Coumarin, 3-(α-acetonylbenzyl)-4-hydroxy- Coumefene Dethmor DL-3-(α-Acetonylbenzyl)-4-hydroxycoumarin Kumader Kumatox NSC 59813 rac-Warfarin Ratron G Rodafarin Rodafarin C Temus W Vampirinip II Vampirinip III W.A.R.F. 42 WARF compound 42 warfarina Warfarine Zoocoumarin DTXSID5023742 81-82-3 DEKWZWCFHUABHE-UHFFFAOYNA-N DEKWZWCFHUABHE-UHFFFAOYSA-N Coumachlor DTXSID8041797 5836-29-3 ULSLJYXHZDTLQK-UHFFFAOYNA-N ULSLJYXHZDTLQK-UHFFFAOYSA-N Coumatetralyl DTXSID8041799 3691-35-8 UDHXJZHVNHGCEC-UHFFFAOYNA-N UDHXJZHVNHGCEC-UHFFFAOYSA-N Chlorophacinone 1H-Indene-1,3(2H)-dione, 2-[(4-chlorophenyl)phenylacetyl]- 1,3-Indandione, 2-[(p-chlorophenyl)phenylacetyl]- 1H-Indene-1,3(2H)-dione, 2-[2-(4-chlorophenyl)-2-phenylacetyl]- 2-[(4-Chlorophenyl)phenylacetyl]-1H-indene-1,3-(2H)-dione 2-[(p-Chlorophenyl)phenylacetyl]-1,3-indandione 2-[2-Phenyl-2-(4-chlorophenyl)acetyl]-1,3-indandione 2-Acetyl-2-(p-chlorophenyl)-2-phenylindan-1,3-dione 2-Phenyl-p-chlorophenylacetyl-1,3-indandione Chlorodiphacinone Chlorophacinon Chlorphacinone Chlorphenacone clorofacinona Liphadione Raticide Raticide-Caid Redentin DTXSID2032348 82-66-6 JYGLAHSAISAEAL-UHFFFAOYSA-N JYGLAHSAISAEAL-UHFFFAOYSA-N Diphacinone DTXSID4032378 83-26-1 RZKYEQDPDZUERB-UHFFFAOYSA-N RZKYEQDPDZUERB-UHFFFAOYSA-N Pindone 1H-Indene-1,3(2H)-dione, 2-(2,2-dimethyl-1-oxopropyl)- 2-Pivalyl-1,3-indandione Pival DTXSID1025930 PR:000007299 PR prothrombin PR:P70375 PR coagulation factor VII (mouse) PR:P16294 PR coagulation factor IX (mouse) PR:O88947 PR coagulation factor X (mouse) CHEBI:33284 CHEBI nutrient D001779 MESH blood coagulation factors CHEBI:28384 CHEBI vitamin K PR:000004191 PR androgen receptor D064417 MESH Vitamin K Epoxide Reductases UBERON:0000062 UBERON organ CHEBI:15422 CHEBI ATP UBERON:0002049 UBERON vasculature PR:000030444 PR osteocalcin PR:P19788 PR matrix Gla protein (mouse) GO:0007599 GO hemostasis MP:0001914 MP hemorrhage GO:0042060 GO wound healing MI:1139 MI carboxylation reaction GO:0006810 GO transport GO:1990748 GO cellular detoxification MP:0001577 MP anemia GO:0042373 GO vitamin K metabolic process GO:0023052 GO signaling GO:0003824 GO catalytic activity MP:0003031 MP acidosis MP:0010128 MP hypovolemia VT:1000152 VT wellness/fitness trait D009026 MESH mortality PCO:0000008 PCO population growth rate GO:0006754 GO ATP biosynthetic process GO:0017077 GO oxidative phosphorylation uncoupler activity MP:0000066 MP osteoporosis D061205 MESH vascular calcification GO:0043687 GO post-translational protein modification 4 WIKI abnormal 1 WIKI increased 2 WIKI decreased 3 WIKI occurrence 7 WIKI functional change Warfarin 2016-11-29T18:42:27 2016-11-29T18:42:27 coumachlor 2016-11-29T18:42:27 2016-11-29T18:42:27 coumatetralyl 2016-11-29T18:42:27 2016-11-29T18:42:27 chlorophacinone 2016-11-29T18:42:27 2016-11-29T18:42:27 diphacinone 2016-11-29T18:42:27 2016-11-29T18:42:27 pindone 2016-11-29T18:42:27 2016-11-29T18:42:27 3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2-benzopyrone 2016-11-29T18:42:27 2016-11-29T18:42:27 WCS_9606 common toxicological species humans 69158 NCBI Rodentia spp. WCS_72873 common ecological species birds WikiUser_17 mammals Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failur Tissue AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) Organ UBERON:0007798 UBERON vascular system AOPWiki 2016-11-29T18:41:29 2017-09-16T10:17:22 Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo Molecular AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tis Cellular AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Hemostasis, Depletion from blood of fully functional carboxylated clotting factors Tissue AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle Molecular AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction Tissue AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Impaired recruitment , Population trajectory Population AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP Molecular CL:0000255 CL eukaryotic cell AOPWiki 2016-11-29T18:41:29 2017-09-16T10:17:25 Osteoporosis and vascular calcification, Bone deterioration Individual AOPWiki 2016-11-29T18:41:30 2016-12-03T16:37:53 Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment Molecular AOPWiki 2016-11-29T18:41:30 2016-12-03T16:37:53 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42eabe8608> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42eac6f720> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42eacc11b0> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42ead45078> AOPWiki 2016-11-29T18:41:37 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42eaddb9b0> AOPWiki 2016-11-29T18:41:37 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42eadf0ef0> AOPWiki 2016-11-29T18:41:37 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b42eae177f8> AOPWiki 2016-11-29T18:41:37 2016-12-03T16:38:04 VKOR inhibition resulting in coagulopathy Brendan Ferreri-Hanberry BY-SA Under Development 1.31 1.0 adjacent High High adjacent High High adjacent High High adjacent High High non-adjacent High High non-adjacent High Moderate non-adjacent Low Low Not Specified Male Not Specified Female High All life stages High High Moderate High <p><a href="#Life_Stage_Applicability">Life Stage Applicability</a>, <a href="#Taxonomic_Applicability"> Taxonomic Applicability</a>, <a href="#Sex_Applicability"> Sex Applicability</a><br /> <em>Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains. </em> Female rodents are less sensitive to ARs than males Female humans are more sensitive ti ARs than males</p> Not Specified Not Specified Not Specified Not Specified Not Specified Not Specified Not Specified AOPWiki 2016-11-29T18:41:17 2023-09-25T16:26:54