{"id":186,"title":"unknown MIE leading to renal failure and mortality","short_name":"unknown MIE renal failure","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:54.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":15,"stressor_name":"Diclofenac sodium"}],"aop_mies":[{"event_id":1114,"event":"Unknown, MIE","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1115,"event":"Increased, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":1088,"event":"Increased, Oxidative Stress","event_type":"KeyEvent"},{"event_id":1097,"event":"Occurrence, renal proximal tubular necrosis","event_type":"KeyEvent"},{"event_id":1098,"event":"Increased, blood potassium concentration","event_type":"KeyEvent"},{"event_id":1106,"event":"Occurrence, cardiac arrhythmia","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":852,"upstream_event_id":1114,"upstream_event":"Unknown, MIE","downstream_event_id":1115,"downstream_event":"Increased, Reactive oxygen species"},{"relation":853,"upstream_event_id":1115,"upstream_event":"Increased, Reactive oxygen species","downstream_event_id":1088,"downstream_event":"Increased, Oxidative Stress"},{"relation":854,"upstream_event_id":1088,"upstream_event":"Increased, Oxidative Stress","downstream_event_id":1097,"downstream_event":"Occurrence, renal proximal tubular necrosis"},{"relation":855,"upstream_event_id":1097,"upstream_event":"Occurrence, renal proximal tubular necrosis","downstream_event_id":1098,"downstream_event":"Increased, blood potassium concentration"},{"relation":856,"upstream_event_id":1098,"upstream_event":"Increased, blood potassium concentration","downstream_event_id":1106,"downstream_event":"Occurrence, cardiac arrhythmia"},{"relation":857,"upstream_event_id":1106,"upstream_event":"Occurrence, cardiac arrhythmia","downstream_event_id":351,"downstream_event":"Increased Mortality"}]}