{"id":18,"title":"PPARα activation in utero leading to impaired fertility in males","short_name":"PPARα activation leading to impaired fertility","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:44.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":227,"event":"Activation, PPARα","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":266,"event":"Decrease, Steroidogenic acute regulatory protein (STAR)","event_type":"KeyEvent"},{"event_id":447,"event":"Reduction, Cholesterol transport in mitochondria","event_type":"KeyEvent"},{"event_id":413,"event":"Reduction, Testosterone synthesis in Leydig cells","event_type":"KeyEvent"},{"event_id":446,"event":"Reduction, fetal/adult testosterone ","event_type":"KeyEvent"},{"event_id":289,"event":"Decrease, Translocator protein (TSPO)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":406,"event":"impaired, Fertility","event_type":"AdverseOutcome"},{"event_id":348,"event":"Malformation, Male reproductive tract","event_type":"AdverseOutcome"}],"relationships":[{"relation":151,"upstream_event_id":266,"upstream_event":"Decrease, Steroidogenic acute regulatory protein (STAR)","downstream_event_id":447,"downstream_event":"Reduction, Cholesterol transport in mitochondria"},{"relation":152,"upstream_event_id":447,"upstream_event":"Reduction, Cholesterol transport in mitochondria","downstream_event_id":413,"downstream_event":"Reduction, Testosterone synthesis in Leydig cells"},{"relation":153,"upstream_event_id":413,"upstream_event":"Reduction, Testosterone synthesis in Leydig cells","downstream_event_id":446,"downstream_event":"Reduction, fetal/adult testosterone "},{"relation":240,"upstream_event_id":227,"upstream_event":"Activation, PPARα","downstream_event_id":266,"downstream_event":"Decrease, Steroidogenic acute regulatory protein (STAR)"},{"relation":241,"upstream_event_id":289,"upstream_event":"Decrease, Translocator protein (TSPO)","downstream_event_id":447,"downstream_event":"Reduction, Cholesterol transport in mitochondria"},{"relation":242,"upstream_event_id":227,"upstream_event":"Activation, PPARα","downstream_event_id":289,"downstream_event":"Decrease, Translocator protein (TSPO)"},{"relation":303,"upstream_event_id":348,"upstream_event":"Malformation, Male reproductive tract","downstream_event_id":406,"downstream_event":"impaired, Fertility"},{"relation":304,"upstream_event_id":446,"upstream_event":"Reduction, fetal/adult testosterone ","downstream_event_id":348,"downstream_event":"Malformation, Male reproductive tract"}]}