{"id":177,"title":"Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality","short_name":"Cox1 inhibition renal failure","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:53.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":190,"stressor_name":"flunixin meglumine"},{"stressor_id":181,"stressor_name":"Ketoprofen"},{"stressor_id":15,"stressor_name":"Diclofenac sodium"},{"stressor_id":191,"stressor_name":"Clofibrate"},{"stressor_id":27,"stressor_name":"Indomethacin"},{"stressor_id":82,"stressor_name":"Ibuprofen"},{"stressor_id":192,"stressor_name":"Meloxicam"},{"stressor_id":86,"stressor_name":"Celecoxib"},{"stressor_id":193,"stressor_name":"nimesulide"},{"stressor_id":182,"stressor_name":"Phenylbutazone"},{"stressor_id":194,"stressor_name":"Carprofen"}],"aop_mies":[{"event_id":1103,"event":"Inhibition, Cyclooxygenase 1 activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1104,"event":"Decreased, Prostaglandin F2alpha concentration, plasma ","event_type":"KeyEvent"},{"event_id":1105,"event":"Occurrence, renal ischemia","event_type":"KeyEvent"},{"event_id":1097,"event":"Occurrence, renal proximal tubular necrosis","event_type":"KeyEvent"},{"event_id":1098,"event":"Increased, blood potassium concentration","event_type":"KeyEvent"},{"event_id":1106,"event":"Occurrence, cardiac arrhythmia","event_type":"KeyEvent"},{"event_id":1088,"event":"Increased, Oxidative Stress","event_type":"KeyEvent"},{"event_id":1096,"event":"Increased, blood uric acid concentration","event_type":"KeyEvent"},{"event_id":1102,"event":"Occurrence, tophi (urate) deposition","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":808,"upstream_event_id":1104,"upstream_event":"Decreased, Prostaglandin F2alpha concentration, plasma ","downstream_event_id":1105,"downstream_event":"Occurrence, renal ischemia"},{"relation":809,"upstream_event_id":1097,"upstream_event":"Occurrence, renal proximal tubular necrosis","downstream_event_id":1098,"downstream_event":"Increased, blood potassium concentration"},{"relation":810,"upstream_event_id":1103,"upstream_event":"Inhibition, Cyclooxygenase 1 activity","downstream_event_id":1104,"downstream_event":"Decreased, Prostaglandin F2alpha concentration, plasma "},{"relation":831,"upstream_event_id":1098,"upstream_event":"Increased, blood potassium concentration","downstream_event_id":1106,"downstream_event":"Occurrence, cardiac arrhythmia"},{"relation":834,"upstream_event_id":1106,"upstream_event":"Occurrence, cardiac arrhythmia","downstream_event_id":351,"downstream_event":"Increased Mortality"},{"relation":850,"upstream_event_id":1105,"upstream_event":"Occurrence, renal ischemia","downstream_event_id":1088,"downstream_event":"Increased, Oxidative Stress"},{"relation":851,"upstream_event_id":1088,"upstream_event":"Increased, Oxidative Stress","downstream_event_id":1097,"downstream_event":"Occurrence, renal proximal tubular necrosis"},{"relation":861,"upstream_event_id":1097,"upstream_event":"Occurrence, renal proximal tubular necrosis","downstream_event_id":1096,"downstream_event":"Increased, blood uric acid concentration"},{"relation":862,"upstream_event_id":1096,"upstream_event":"Increased, blood uric acid concentration","downstream_event_id":1102,"downstream_event":"Occurrence, tophi (urate) deposition"},{"relation":863,"upstream_event_id":1102,"upstream_event":"Occurrence, tophi (urate) deposition","downstream_event_id":1097,"downstream_event":"Occurrence, renal proximal tubular necrosis"},{"relation":864,"upstream_event_id":1096,"upstream_event":"Increased, blood uric acid concentration","downstream_event_id":1088,"downstream_event":"Increased, Oxidative Stress"}]}