UBERON:0000977 UBERON pleura PR:000036194 PR eukaryotic protein UBERON:0001136 UBERON mesothelium D008654 MESH mesothelioma GO:0008219 GO cell death GO:0006954 GO inflammatory response MP:0003674 MP oxidative stress GO:0046903 GO secretion GO:0008283 GO cell proliferation HP:0100001 HP Malignant mesothelioma 1 WIKI increased 10116 NCBI rat persistent, cytotoxicity (pleura or peritoneum) Cellular UBERON:0000977 UBERON pleura AOPWiki 2016-11-29T18:41:29 2017-09-16T10:17:15 Increased, inflammation Cellular AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Increased, Oxidative Stress Molecular CL:0000255 CL eukaryotic cell AOPWiki 2016-11-29T18:41:29 2022-02-03T14:20:13 Increased, secretion of local growth factors Cellular CL:0000255 CL eukaryotic cell AOPWiki 2016-11-29T18:41:28 2017-09-16T10:17:02 Increased, Cell Proliferation (mesothelium) Cellular UBERON:0001136 UBERON mesothelium AOPWiki 2016-11-29T18:41:29 2017-09-16T10:17:16 Increased, mesotheliomas Tissue AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4313797d28> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43137dcb58> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b431381ac50> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43138b0a20> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4313966780> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:04 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43139ac898> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:04 Chronic cytotoxicity of the serous membrane and mesotheliomas. Evgeniia Kazymova <p>Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p> BY-SA 1.29 1.0 <p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p> <p>&nbsp;</p> adjacent Not Specified High adjacent Not Specified High adjacent Not Specified High non-adjacent Not Specified Moderate non-adjacent Not Specified Moderate non-adjacent Not Specified High High <p>1. Bateson, T. F., Benson, R., Christensen, K. Y., Cooper, G., DeVoney, D., Gwinn, M., R., and Kopylev, L. (2014). Toxicological Review of Libby Amphibole Asbestos. In (IRIS, Ed.) Eds.) doi, pp. 685. US Environmental Protection Agency, Washington, DC.</p> <p>2. Rittinghausen, S., Hackbarth, A., Creutzenberg, O., Ernst, H., Heinrich, U., Leonhardt, A., and Schaudien, D. (2014). The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats. Particle and fibre toxicology 11, 59, 10.1186/s12989-014-0059-z.</p> <p>3. Suzui, M., Futakuchi, M., Fukamachi, K., Numano, T., Abdelgied, M., Takahashi, S., Ohnishi, M., Omori, T., Tsuruoka, S., Hirose, A., Kanno, J., Sakamoto, Y., Alexander, D. B., Alexander, W. T., Jiegou, X., and Tsuda, H. (2016). Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors. Cancer science doi: 10.1111/cas.12954, 10.1111/cas.12954.</p> AOPWiki 2016-11-29T18:41:17 2023-09-25T16:26:53