{"id":171,"title":"Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.","short_name":"Chronic cytotoxicity of the serous membrane and mesotheliomas.","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:53.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[],"aop_kes":[{"event_id":1086,"event":"persistent, cytotoxicity (pleura or peritoneum)","event_type":"KeyEvent"},{"event_id":1087,"event":"Increased, inflammation","event_type":"KeyEvent"},{"event_id":1088,"event":"Increased, Oxidative Stress","event_type":"KeyEvent"},{"event_id":1032,"event":"Increased, secretion of local growth factors","event_type":"KeyEvent"},{"event_id":1089,"event":"Increased, Cell Proliferation (mesothelium)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1090,"event":"Increased, mesotheliomas","event_type":"AdverseOutcome"}],"relationships":[{"relation":795,"upstream_event_id":1086,"upstream_event":"persistent, cytotoxicity (pleura or peritoneum)","downstream_event_id":1087,"downstream_event":"Increased, inflammation"},{"relation":796,"upstream_event_id":1086,"upstream_event":"persistent, cytotoxicity (pleura or peritoneum)","downstream_event_id":1088,"downstream_event":"Increased, Oxidative Stress"},{"relation":797,"upstream_event_id":1087,"upstream_event":"Increased, inflammation","downstream_event_id":1032,"downstream_event":"Increased, secretion of local growth factors"},{"relation":798,"upstream_event_id":1088,"upstream_event":"Increased, Oxidative Stress","downstream_event_id":1032,"downstream_event":"Increased, secretion of local growth factors"},{"relation":799,"upstream_event_id":1032,"upstream_event":"Increased, secretion of local growth factors","downstream_event_id":1089,"downstream_event":"Increased, Cell Proliferation (mesothelium)"},{"relation":800,"upstream_event_id":1089,"upstream_event":"Increased, Cell Proliferation (mesothelium)","downstream_event_id":1090,"downstream_event":"Increased, mesotheliomas"}]}