1912-24-9 MXWJVTOOROXGIU-UHFFFAOYSA-N MXWJVTOOROXGIU-UHFFFAOYSA-N Atrazine 1,3,5-Triazine-2,4-diamine, 6-chloro-N-ethyl-N'-(1-methylethyl)- 1,3,5-Triazine-2,4-diamine, 6-chloro-N2-ethyl-N4-(1-methylethyl)- 1-Chloro-3-ethylamino-5-isopropylamino-2,4,6-triazine 2-Chloro-4-(ethylamino)-6-(2-propylamino)-s-triazine 2-Chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine 2-Chloro-4-(ethylamino)-6-(isopropylamino)triazine 2-Chloro-4-ethylamineisopropylamine-s-triazine 2-Chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine 2-Chloro-4-ethylamino-6-isopropylamino-s-triazine 2-Ethylamino-4-isopropylamino-6-chloro-s-triazine 6-Chloro-4-(ethylamino)-2-(isopropylamino)-s-triazine 6-Chloro-N-ethyl-N'-(1-methylethyl)-1,3,5-triazine-2,4-diamine AAtrex Nine-O Akticon Aktikon Aktikon PK Aktinit A Aktinit PK Argezin Atragranz Atranex Atranex 80WP Atraphyt Atrataf Atrazin atrazina Azoprim Chromozin Farmozine Gesamprim Gesaprim Gesaprim 50 Gesaprim 500 Gesaprim L Herbatoxol Hungazin Hungazin PK NSC 163046 Nu-Trazine Oleogesaprim Oleogesaprim 200 Primatol A Primoleo Radazin Radazin T s-Triazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)- Triazine A 1294 Zealin L Zeazine DTXSID9020112 D007987 MESH Gonadotropin Releasing Hormone CHEBI:81568 CHEBI Luteinizing hormone CHEBI:50114 CHEBI estrogen CL:0000439 CL prolactin secreting cell D000236 MESH Adenoma GO:0046879 GO hormone secretion GO:0060209 GO estrus MP:0001928 MP abnormal ovulation D006965 MESH hyperplasia D006984 MESH hypertrophy HP:0002893 HP Pituitary adenoma 2 WIKI decreased 5 WIKI delayed 9 WIKI disrupted 1 WIKI increased atrazine 2016-11-29T18:42:27 2016-11-29T18:42:27 10116 NCBI SD rat Decreased, GnRH pulsatility/release in hypothalamus Cellular CL:0011111 CL gonadotropin releasing neuron AOPWiki 2016-11-29T18:41:29 2017-09-16T10:17:11 Decreased, LH Surge from anterior pituitary Cellular AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 prolonged, estrus Individual AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 interruption, Ovulation Individual AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Increased, circulating estrogen levels Organ AOPWiki 2016-11-29T18:41:29 2016-12-03T16:37:53 Increased, lactotroph hyperplasia and hypertrophy Cellular CL:0000439 CL prolactin secreting cell AOPWiki 2016-11-29T18:41:29 2017-09-16T10:17:13 Increased, adenomas (pituitary) Tissue UBERON:0000007 UBERON pituitary gland AOPWiki 2016-11-29T18:41:29 2017-09-16T10:17:14 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4300521070> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4300702330> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43007295e8> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43007607f0> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43007d1d60> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4300857d70> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4310b6cb90> AOPWiki 2016-11-29T18:41:36 2016-12-03T16:38:03 GnRH pulse disruption and pituitary tumors Agnes Aggy <p>Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p> BY-SA 1.29 1.0 <p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p> adjacent Not Specified High adjacent Not Specified High adjacent Not Specified High adjacent Not Specified High non-adjacent Not Specified High non-adjacent Not Specified High non-adjacent Not Specified High High Female High Not Specified <p>1. O&#39;Connor, J. C., Davis, L. G., Frame, S. R., and Cook, J. C. (2000). Detection of dopaminergic modulators in a tier I screening battery for identifying endocrine-active compounds (EACs). Reproductive toxicology 14(3), 193-205.</p> AOPWiki 2016-11-29T18:41:17 2023-09-25T16:26:53