{"id":169,"title":"GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.","short_name":"GnRH pulse disruption and pituitary tumors","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-09-25T16:26:53.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":177,"stressor_name":"atrazine"}],"aop_mies":[],"aop_kes":[{"event_id":1071,"event":"Decreased, GnRH pulsatility/release in hypothalamus","event_type":"KeyEvent"},{"event_id":1072,"event":"Decreased, LH Surge from anterior pituitary","event_type":"KeyEvent"},{"event_id":1075,"event":"prolonged, estrus","event_type":"KeyEvent"},{"event_id":1074,"event":"interruption, Ovulation","event_type":"KeyEvent"},{"event_id":1076,"event":"Increased, circulating estrogen levels","event_type":"KeyEvent"},{"event_id":1081,"event":"Increased, lactotroph hyperplasia and hypertrophy","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1082,"event":"Increased, adenomas (pituitary)","event_type":"AdverseOutcome"}],"relationships":[{"relation":783,"upstream_event_id":1071,"upstream_event":"Decreased, GnRH pulsatility/release in hypothalamus","downstream_event_id":1072,"downstream_event":"Decreased, LH Surge from anterior pituitary"},{"relation":784,"upstream_event_id":1072,"upstream_event":"Decreased, LH Surge from anterior pituitary","downstream_event_id":1075,"downstream_event":"prolonged, estrus"},{"relation":785,"upstream_event_id":1072,"upstream_event":"Decreased, LH Surge from anterior pituitary","downstream_event_id":1074,"downstream_event":"interruption, Ovulation"},{"relation":786,"upstream_event_id":1075,"upstream_event":"prolonged, estrus","downstream_event_id":1076,"downstream_event":"Increased, circulating estrogen levels"},{"relation":787,"upstream_event_id":1074,"upstream_event":"interruption, Ovulation","downstream_event_id":1076,"downstream_event":"Increased, circulating estrogen levels"},{"relation":788,"upstream_event_id":1076,"upstream_event":"Increased, circulating estrogen levels","downstream_event_id":1081,"downstream_event":"Increased, lactotroph hyperplasia and hypertrophy"},{"relation":789,"upstream_event_id":1081,"upstream_event":"Increased, lactotroph hyperplasia and hypertrophy","downstream_event_id":1082,"downstream_event":"Increased, adenomas (pituitary)"}]}